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胃癌组织的CPXCR1水平及临床意义

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  • NETL
  • NSTL
  • 万方数据
目的 探讨胃癌组织中CPX染色体候选区域 1(CPXCR1)的水平及其预后价值.方法 选取 2019 年 1 月至2022 年12 月于本院行胃癌根治术的患者95 例,采用实时荧光定量PCR检测CPXCR1 在95 例胃癌组织及对应癌旁组织中的表达差异,分析CPXCR1 水平与胃癌患者临床病理特征的关系,采用Kaplan-Meier生存曲线并基于Cox比例风险模型分析CPXCR1 在胃癌患者预后预测中的价值.结果 95 例胃癌组织的CPXCR1 水平为 0.791±0.035,低于癌旁组织的 1.197±0.026(t=9.217,P＜0.001).分层分析显示CPXCR1 表达与胃癌患者的性别(χ2=0.608,P=0.436)、年龄(χ2=1.935,P=0.164)、肿瘤位置(χ2=0.892,P=0.640)、Lauren分型(χ2=3.064,P=0.216)、分化程度(χ2=0.253,P=0.615)和T分期(χ2=1.772,P=0.183)无关,而与TNM分期(χ2=3.903,P=0.048)、肿瘤大小(χ2=6.663,P=0.010)和淋巴结转移(χ2=4.915,P=0.027)有关.单因素分析显示CPXCR1 表达与胃癌患者的总生存期(OS)有关,其中高表达患者的中位OS未达,优于低表达者的 37 个月(HR=2.414,95%CI:1.314～4.435,P=0.005);多因素分析显示CPXCR1 高表达是胃癌预后不良的危险因素(HR=2.136,95%CI:1.096～3.956,P=0.022).结论 CPXCR1 在胃癌中低表达且与不良预后相关,CPXCR1 是一个独立的预后风险因素,也是胃癌诊断和治疗的潜在生物标志物.
Expression and clinical significance of CPXCR1 in gastric cancer tissues
Objective To explore the level of CPX chromosome candidate region 1(CPXCR1)in gastric cancer tissues and its value in evaluating the prognosis of gastric cancer patients.Methods Ninety-five patients who underwent radical gastrectomy for gastric cancer in our hospital from January 2019 to December 2022 were selected.Real-time fluorescence quantitative PCR was used to detect the differential expression of CPXCR1 in gastric cancer tissues and corresponding adjacent tissues.The relationship between CPXCR1 levels and clinical pathological characteristics of gastric cancer patients was analyzed.The Kaplan Meier survival curve and Cox proportional risk model were used to analyze the value of CPXCR1 in predicting the prognosis of gastric cancer patients.Results The level of CPXCR1 in 95 gastric cancer tissues was 0.791±0.035,which was lower than 1.197±0.026 in adjacent tissues(t=9.217,P＜0.001).Layered analysis showed that the expression of CPXCR1 was not related to gender(χ2=0.608,P=0.436),age(χ2=1.935,P=0.164),tumor location(χ2=0.892,P=0.640),Lauren classification(χ2=3.064,P=0.216),differentiation degree(χ2=0.253,P=0.615)and T stage(χ2=1.772,P=0.183)in gastric cancer patients(P＞0.05),but was related to TNM stage(χ2=3.903,P=0.048),tumor size(χ2=6.663,P=0.010)and lymph node metastasis(χ2=4.915,P=0.027).Univariate analysis showed that the expression of CPXCR1 was associated with overall survival(OS)in gastric cancer patients,with the unreached median OS in high expression patients,which was better than 37 months in low expression patients(HR=2.414,95%CI:1.314-4.435,P=0.005).Multivariate analysis showed that low expression of CPXCR1 was a risk factor for poor prognosis in gastric cancer(HR=2.136,95%CI:1.096-3.956,P=0.022).Conclusion CPXCR1 is lowly expressed in gastric cancer and is associated with poor prognosis.CPXCR1 is an independent prognostic risk factor and a potential biomarker for the diagnosis and treatment of gastric cancer.

Gastric cancerCPX chromosome candidate region 1Clinical significancePrognosis

李大鹏、吴颂、成伟丽、张宁、孙明琪

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066000 河北秦皇岛 天津市肿瘤医院秦皇岛医院消化肿瘤科

066000 秦皇岛市中医医院治未病中心

胃癌 CPX染色体候选区域1 临床意义 预后

2024

临床肿瘤学杂志
解放军第八一医院

临床肿瘤学杂志

CSTPCD
影响因子：1.583
ISSN：1009-0460
年,卷(期)：2024.29(7)