组织RP11-757G1.5水平对胃癌根治术患者预后的评估价值
Prognostic value of tissue RP11-757G1.5 level in patients with gastric cancer undergoing radical gastrectomy
孙佳兴 1徐飞 1尹乐 1吴亚娟 1姜飞 1蔡静清 1苗丽丽1
作者信息
- 1. 067000 河北承德 承德市第三医院检验科
- 折叠
摘要
目的 探讨胃癌组织中的长链非编码RNA RP11-757G1.5 水平及其预后评估价值.方法 采用实时荧光定量PCR检测RP11-757G1.5 在 98 对胃癌组织及对应癌旁组织中的表达差异,基于临床病理资料和随访数据分析 RP11-757G1.5 的临床价值.结果 胃癌组织的RP11-757G1.5 水平高于癌旁组织(4.424±0.173 vs.1.686±0.076,t=14.508,P＜0.001).RP11-757G1.5 在胃癌组织中表达显著与TNM分期(χ2=7.721,P=0.006)、分化程度(χ2=8.279,P=0.004)、T分期(χ2=5.528,P=0.019)和癌胚抗原状态(χ2=4.125,P=0.042)有关.RP11-757G1.5 低表达者的中位无病生存期未达,优于高表达者的 38 个月(HR=2.714,95%CI:1.613～4.743,P=0.008),经多因素分析证实RP11-757G1.5 高表达是胃癌预后不良的危险因素(HR=2.438,95%CI:1.307～4.546,P=0.016).结论 RP11-757G1.5 表达上调,是胃癌患者预后不良的预测因子,可能是一个有前途的胃癌生物标志物和治疗靶点.
Abstract
Objective To investigate the level of long non-coding RNA RP11-757G1.5 in gastric cancer tissues and its prognostic value.Methods Ninety-eight pairs of gastric cancer tissues and corresponding adjacent tissues were collected.Differential expression of RP11-757G1.5 between groups were assessed via real-time quantitative PCR.The clinical value of RP11-757G1.5 was analyzed based on clinical pathological data and follow-up data.Results The RP11-757G1.5 level in gastric cancer tissues was higher than that in adjacent tissues(4.424±0.173 vs.1.686±0.076,t=14.508,P＜0.001).RP11-757G1.5 level in gastric cancer tissues was associated with TNM staging(χ2=7.721,P=0.006),differentiation degree(χ2=8.279,P=0.004),T staging(χ2=5.528,P=0.019),and carcinoembryonic antigen status(χ2=4.125,P=0.042).The median disease-free survival of individuals with low RP11-757G1.5 expression was not reached,better than 38 months of individuals with high expression(HR=2.714,95%CI:1.613-4.743,P=0.008).High RP11-757G1.5 expression was a risk factor for poor prognosis in gastric cancer(HR=2.438,95%CI:1.307-4.546,P=0.016).Conclusion Upregulation of RP11-757G1.5 expression is a predictive factor for poor prognosis in gastric cancer patients and may be a promising biomarker and therapeutic target for gastric cancer.
关键词
胃癌/长链非编码RNA/RP11-757G1.5/临床意义Key words
Gastric cancer/Long non-coding RNA/RP11-757G1.5/Clinical significance引用本文复制引用
出版年
2024
NETL
NSTL
万方数据