Prognostic value of tissue RP11-757G1.5 level in patients with gastric cancer undergoing radical gastrectomy
Objective To investigate the level of long non-coding RNA RP11-757G1.5 in gastric cancer tissues and its prognostic value.Methods Ninety-eight pairs of gastric cancer tissues and corresponding adjacent tissues were collected.Differential expression of RP11-757G1.5 between groups were assessed via real-time quantitative PCR.The clinical value of RP11-757G1.5 was analyzed based on clinical pathological data and follow-up data.Results The RP11-757G1.5 level in gastric cancer tissues was higher than that in adjacent tissues(4.424±0.173 vs.1.686±0.076,t=14.508,P＜0.001).RP11-757G1.5 level in gastric cancer tissues was associated with TNM staging(χ2=7.721,P=0.006),differentiation degree(χ2=8.279,P=0.004),T staging(χ2=5.528,P=0.019),and carcinoembryonic antigen status(χ2=4.125,P=0.042).The median disease-free survival of individuals with low RP11-757G1.5 expression was not reached,better than 38 months of individuals with high expression(HR=2.714,95%CI:1.613-4.743,P=0.008).High RP11-757G1.5 expression was a risk factor for poor prognosis in gastric cancer(HR=2.438,95%CI:1.307-4.546,P=0.016).Conclusion Upregulation of RP11-757G1.5 expression is a predictive factor for poor prognosis in gastric cancer patients and may be a promising biomarker and therapeutic target for gastric cancer.
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