Relationship analysis of BGLAP expression with clinical pathological characteristics and prognosis in osteosarcoma tissues
Objective To investigate the expression of bone gamma-carboxyglutamate protein(BGLAP)in osteosarcoma and its correlation with clinical pathological characteristics and prognosis.Methods Seventy pairs of cancer tissues and adjacent normal tissues were collected from patients with osteosarcoma.Expression level of BGLAP in the above tissues were investigated via immunohistochemistry and real-time quantitative PCR(qPCR).Seventy patients were divided into low expression group and high expression group based on the mean expression of BGLAP gene detected by qPCR in osteosarcoma tissues.Clinical and pathological parameters of two groups were compared,and survival assessment and multivariate analysis were conducted based on follow-up data.Results Compared with normal tissue adjacent to cancer,the expression level of BGLAP in osteosarcoma tissue was elevated(3.02±0.27 vs.1.00±0.08,P＜0.01).BGLAP expression was closely related to differentiation degree,distal metastasis,and Enneking staging(P＜0.05).The median overall survival and 5-year survival rate of the BGLAP low expression group were 40 months and 55.56%,better than 28 months and 26.92%of the high expression group,and the difference was statistically significant(P＜0.05).Multivariate analysis showed that low expression of BGLAP was an independent protective factor for the prognosis of osteosarcoma patients(OR=0.215,95%CI:0.095-0.485,P＜0.001).Conclusion High expression of BGLAP may be involved in the occurrence,development,invasion,and distant metastasis of osteosarcoma,and has the potential to serve as a diagnostic,malignant,and prognostic indicator for osteosarcoma.
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