卵巢癌免疫逃逸过程中自然杀伤细胞功能与机制的研究进展
Advances in research on the functions and mechanisms of NK cells during immune evasion in ovarian cancer
季春雅 1布沙来木·木哈买 1蒲佳纹 1寸云花 1王露瑶 1付子毅 2阮红杰1
作者信息
- 1. 210004 南京 南京医科大学附属妇产医院 南京市妇幼保健院妇科
- 2. 210029 南京医科大学附属第一医院妇幼研究中心乳腺病研究中心
- 折叠
摘要
卵巢癌的肿瘤微环境能通过多种途径抑制免疫细胞,促进卵巢癌细胞的免疫逃逸,最终导致卵巢癌的高转移和高复发.手术和铂类-紫杉醇类联合化疗是卵巢癌的一线治疗,但约70%的患者会经历复发,因此迫切需要新的治疗手段来为患者提供新的治疗选择.自然杀伤(NK)细胞是天然免疫系统的重要组成部分,其抗肿瘤功能的激活主要依赖于表面激活性受体和抑制性受体信号间的平衡,但是在卵巢癌的肿瘤微环境中NK细胞的抗肿瘤功能被显著抑制.本文重点分析了卵巢癌免疫逃逸过程中NK细胞功能改变的分子机制和相关治疗进展,以寻求解除NK细胞免疫抑制、改善卵巢癌患者预后的有效策略.
Abstract
The tumor microenvironment of ovarian cancer has the capacity to impede immune cells through various pathways.These mechanisms facilitate immune evasion of ovarian cancer cells,ultimately resulting in elevated rates of metastasis and recurrence.The primary therapeutic approach for ovarian cancer involves surgery and platinum-paclitaxel combination chemotherapy as first-line treatment,yet approximately 70%of patients will encounter disease recurrence,underscoring the critical necessity for novel treatment modalities.Natural killer(NK)cells,integral components of the innate immune system,play a pivotal role in anti-tumor immunity,with their efficacy contingent upon a delicate equilibrium between activating and inhibitory receptor signals.Nonetheless,the anti-tumor capabilities of NK cells are markedly suppressed within the tumor microenvironment of ovarian cancer.This article examines the molecular mechanisms underlying the changes in NK cells'function during the immune evasion process of ovarian cancer,as well as the advancements in treatment.The aim is to identify effective strategies for alleviating NK cells immunosuppression and enhancing the prognosis of patients with ovarian cancer.
关键词
卵巢癌/免疫逃逸/自然杀伤细胞/肿瘤微环境Key words
Ovarian cancer/Immune escape/Natural killer cells/Tumor microenvironment引用本文复制引用
出版年
2024
NETL
NSTL
万方数据