Advances in research on the functions and mechanisms of NK cells during immune evasion in ovarian cancer
The tumor microenvironment of ovarian cancer has the capacity to impede immune cells through various pathways.These mechanisms facilitate immune evasion of ovarian cancer cells,ultimately resulting in elevated rates of metastasis and recurrence.The primary therapeutic approach for ovarian cancer involves surgery and platinum-paclitaxel combination chemotherapy as first-line treatment,yet approximately 70%of patients will encounter disease recurrence,underscoring the critical necessity for novel treatment modalities.Natural killer(NK)cells,integral components of the innate immune system,play a pivotal role in anti-tumor immunity,with their efficacy contingent upon a delicate equilibrium between activating and inhibitory receptor signals.Nonetheless,the anti-tumor capabilities of NK cells are markedly suppressed within the tumor microenvironment of ovarian cancer.This article examines the molecular mechanisms underlying the changes in NK cells'function during the immune evasion process of ovarian cancer,as well as the advancements in treatment.The aim is to identify effective strategies for alleviating NK cells immunosuppression and enhancing the prognosis of patients with ovarian cancer.
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