The ratio of NLR to HDL-C in multiple myeloma and its clinical significance
Objective To detect the expression of high density lipoprotein cholesterol(HDL-C)in peripheral blood of patients with multiple myeloma(MM),and further investigate the relationship of NLR/HDL-C ratio(NHR)with clinicopathological features,diagnosis and prognosis.Methods The clinical data of 90 MM patients from June 2018 to September 2023 were retrospectively analyzed,and the peripheral blood was collected from 50 volunteers who underwent physical examination during the same period.The contents of neutrophil,lymphocyte and HDL-C in peripheral blood were detected,NHR was calculated,and the relationship between NHR and clinicopathological features of MM was analyzed.Receiver characteristic operating(ROC)curve was used to analyze the diagnostic value of NHR for MM.Overall survival(OS)was plotted by Kaplan-Meier method,and Cox regression model was used to analyze the independent factors affecting OS.Results The NHR of peripheral blood of MM patients was 2.65±0.34,which was higher than that of healthy control group(1.20±0.19),and the difference was statistically significant(P<0.05).ROC curve results showed that when the NHR cut-off value was 1.765,the sensitivity for diagnosis of MM was 97.8%,the specificity was 94.0%,and the area under the curve(AUC)was 0.973(P<0.05).NHR was correlated with β2 microglobulin level and ISS stage(P<0.05).Cox regression analysis showed that platelet level,ISS stage and NHR were independent prognostic factors for OS(P<0.05).Kaplan-Meier method showed that the median OS of patients with low NHR level was 48 months,which was significantly higher than 21 months of patients with high NHR level,and the difference was statistically significant(HR=0.35,95%CI:0.18-0.54,P<0.001).Conclusion NHR is closely related to the occurrence and development of MM,and can be used as a molecular marker for the diagnosis and prognosis of MM.
Multiple myelomaNeutrophil-lymphocyte ratioHigh density lipoprotein cholesterolDiagnosisPrognosis
NETL
NSTL
万方数据
