壶腹癌病理分型与临床应用
Pathological classification and clinical application of ampullary carcinoma
陈歆妮 1王锋 1龚新雷1
作者信息
- 1. 210002 南京 南京大学医学院附属金陵医院肿瘤科
- 折叠
摘要
壶腹部周围区域解剖结构复杂,涉及胆总管下段、胰头、壶腹和十二指肠等多个部位.壶腹肿瘤起源,一方面通过主要病灶在宏观上的位置来确定,另一方面通过免疫组织化学来定论,如肠型与胰胆管型.而组织学分型又受到染色方法、阳性阈值和病理科医师主观评估的限制.尽管多数文献认为壶腹癌恶性程度相对胰头癌较低,但对于其亚型评估的不一致性阻碍了临床诊断与治疗的进展,且国内相关性数据十分有限.本文通过整理近年来国内外报道的壶腹癌病理分型的方法和标准,以及基于此类方法实现的个体化抗肿瘤方案与临床应用的相关内容,旨在为临床治疗及预后判断提供更多的参考依据.
Abstract
Objective The anatomy of the periampullary region is complex.The origin of tumors in this area can be determined both by macroscopic location of main lesions and through immunohistochemical analysis,such as intestinal type and pancreaticobiliary type.However,histopathological type is limited by factors like staining methods,positive thresholds,and subjective evaluation by pathologists.Although most literature suggests that ampullary cancer has relatively low malignancy compared to pancreatic cancer,the lack of consistency in subtype assessment hinders progress in clinical diagnosis and treatment,with limited relevant data available domestically.This article aims to provide more references for clinical treatment and postoperative judgment by summarizing recent domestic and foreign reports on methods and standards for pathological typing of ampullary cancer,as well as content related to individualized anti-tumor schemes and clinical applications based on these methods.
关键词
壶腹癌/肠型/胰胆管型/混合型/组织学分型Key words
Ampullary carcinoma/Intestinal type/Pancreatobiliary type/Mixed type/Histopathological type引用本文复制引用
出版年
2024
NETL
NSTL
万方数据