Application value of three-dimensional reconstruction in combined cryoablation and thermal ablation for locally advanced pancreatic cancer
Objective To explore the application value of three-dimensional(3D)reconstruction technology in tumor localization,ablation range assessment,and treatment planning for local advanced pancreatic cancer(LAPC)during intraoperative combined cryoablation and hyperthermia(ICCH).Methods A retrospective analysis was conducted on 19 patients with LAPC who underwent ICCH at Liaoning Cancer Hospital from January 2023 to April 2024.All patients underwent preoperative full abdominal CT scans and enhanced scans,followed by 3D reconstruction of the pancreatic tumors and surrounding vessels using specialized software.The optimal ablation path and strategy were determined based on the 3D reconstructed images.The maximum diameter and volume of the tumors were measured and compared on both CT and 3D reconstructed images before and after ablation.Surgical time,intraoperative blood loss,preoperative and postoperative laboratory indicators,VAS scores,and complications were recorded.Results All 19 patients successfully underwent the combined ablation procedure,and postoperative histopathology confirmed pancreatic cancer.There were no perioperative deaths.The postoperative fasting time was(3.0±0.6)days,and the postoperative hospital stay was(8.8+2.8)days.Postoperative pancreatic fistula occurred in 2 patients(10.5％),and abdominal bleeding occurred in 1 patient(5.3％).No other complications were observed,and all patients were discharged after successful treatment.There were statistically significant differences in white blood cell count,hemoglobin,and albumin levels before and after surgery(P＜0.01).The maximum tumor diameter before and after surgery showed a statistically significant difference(P=0.002),but there was no significant difference in tumor volume(P=0.248).The comparison of preoperative and postoperative VAS scores showed a statistically significant difference(P＜0.001).Conclusion Preoperative 3D reconstruction can assist in formulating the ICCH plan for patients with locally advanced pancreatic cancer,and the procedure is safe and feasible during surgery.
Locally advanced pancreatic cancerCombined cryoablation and thermal ablationThree-dimensional(3D)reconstruction technology
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