Research progress on reshaping of immune environment in gastric cancer
Gastric cancer is a malignant tumor with a high incidence and poor prognosis in China.Radical surgery,radiotherapy and chemotherapy,as well as newly developed targeted therapy and immunotherapy,have not yet completely changed the treatment dilemma of advanced gastric cancer.An increasing amount of research evidence suggests that the immune microenvironment and systemic immune environment of tumors have a significant impact on treatment efficacy and survival prognosis.Therefore,this article briefly describes the current research status of the immune microenvironment and systemic immune environment,and reviews the research progress of emerging methods such as monoclonal antibodies targeting programmed cell dealth 1(PD-1)/programmed cell dealth ligland 1(PD-L1),Claudin 18.2,and the effects of the above methods including radiotherapy and chemotherapy on the local microenvironment and systemic immune environment of gastric cancer.It explores the possible ways to economically and efficiently monitor and reshape the immune microenvironment and systemic immune environment of gastric cancer,in order to provide new ideas for the research of personalized comprehensive treatment strategies for gastric cancer.
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