Significance of inflammation index in predicting radiation pneumonia induced by radical radiotherapy in patients with locally advanced non-small cell lung cancer
Objective To evaluate the significance of monocyte to lymphocyte ratio(MLR)and other blood biomarkers in predicting radiation pneumonia after radiotherapy in patients with locally advanced non-small cell lung cancer(LA-NSCLC).Methods One hundred and six patients with LA-NSCLC who received chemoradiotherapy between April 2019 and April 2023 were collected.Radiation pneumonia group and control group were divided according to whether radiation pneumonia occurred after radiotherapy.Patient demographic characteristics,clinical data,laboratory findings,and treatment parameters were analyzed.Multivariate Logistic regression analysis of the factors affecting the occurrence of radiation pneumonia.Survival curve was drawn by Kaplan-Meier method,and survival difference was tested by Log-rank.Results Radiation pneumonia occurred in 61 patients.The 1-,2-and 3-year survival rates of patients with radiation pneumonia were much lower than those of control group(P=0.017).The proportion of patients with ECOG PS 1-2 score,PTV,V5 and V20 in the radiation pneumonia group were also higher than those in the control group(P<0.05).Compared with the control group,the absolute lymphocyte count before radiotherapy was slightly lower in the radiation pneumonia group(P=0.019),and the CRP level(P=0.037)and MLR(P<0.001)were higher.Multivariate Logistic model analysis showed that ECOG score(P=0.043),double lung V20(P=0.021),CRP(P=0.008)and MLR(P=0.007)were the factors affecting radiation pneumonia.The median OS in the MLR<0.51 group was lower than that in the MLR≥0.51 group at 32.2 months(ranging from 7.7 to 44.5 months),the difference was statistically significant(P=0.004).Conclusion MLR is a biomarker for predicting radiation pneumonia in patients with stage Ⅲ LA-NSCLC after chemoradiotherapy.
Locally advanced non-small cell lung cancer(LA-NSCLC)Monocyte to lymphocyte ratio(MLR)Radiation pneumoniaPrognosis
NETL
NSTL
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