Expression and clinical significance of LINC00623 in colorectal cancer
Objective To explore the expression of LINC00623 in colorectal cancer tissue and its relationship with prognosis of colorectal cancer.Methods Eighty-six patients with colorectal cancer who underwent surgical treatment from September 2017 to September 2018 were selected,and cancer tissue and adjacent tissue specimens were collected.Real time fluorescence quantitative PCR(qPCR)was used to detect the expression level of LINC00623 in tissues and analyze its relationship with the clinical and pathological characteristics of colorectal cancer.Kaplan meier method was used to draw survival curves,and Cox risk proportional regression model was used to analyze factors affecting prognosis.Results The expression level of LINC00623 in colorectal cancer tissue was 3.002±1.55,which was higher than that in adjacent tissues by 1±0.43(P<0.05).ROC curve analysis shows that the area under the curve for diagnosing colorectal cancer at the LINC00623 level is 0.921,with sensitivity and specificity of 74.4%and 97.7%.The level of LINC00623 is related to TNM staging,lymph node metastasis,and depth of infiltration in colorectal cancer(P<0.05).The 5-year survival rate of the high expression group of LINC00623 was 48.3%,lower than the 74.3%of the low expression group of LINC00623,and the difference was statistically significant(P<0.05).Cox risk proportional regression analysis showed that LINC00623 expression,TNM staging,differentiation degree,and infiltration depth are factors affecting the prognosis of colorectal cancer.Conclusion The upregulation of LINC00623 expression in colorectal cancer is closely related to clinical pathological characteristics and prognosis,and can provide a certain clinical reference basis for the diagnosis and prognosis evaluation of colorectal cancer.
Colorectal cancerLong non-coding RNAPrognosisClinicopathological features
NETL
NSTL
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