Clinicopathological analysis of primary and metastatic mucinous ovarian adenocarcinoma
Objective To explore the differences in diagnosis and prognosis between primary ovarian mucinous adenocarcinoma(pMOC)and metastatic ovarian mucinous adenocarcinoma(mMOC).Methods From January 2009 to May 2024,60 cases of MOC patients were diagnosed,including 39 cases of pMOC,and 21 cases of mMOC.The clinicopathological characteristics of pMOC and mMOC were compared,and their imaging manifestations,routine pathology,immunohistochemical staining,and survival status were observed.Results There were significant differences in terms of age,menopausal status,tumor size,preoperative serum markers(CA125,CEA)levels,ovarian involvement and ascites status between pMOC and mMOC patients.The imaging findings showed that pMOC usually presented as unilateral lesions,large in size,well-defined borders,and may contain cystic and solid components within.In contrast,mMOC tended to involve bilateral lesions,with smaller tumor size and irregular shape,and may be accompanied by marked ascites.The routine pathological results showed that the HE staining in pMOC tissues showed glandular structures,while the mMOC tissues showed mostly scattered glandular small clusters.The positive expression rates of CK7 and PAX8 in pMOC tissues were higher than those in mMOC,while the positive expression rates of CK20 and CDX2 in mMOC tissues were higher than those in pMOC.The median overall survival(OS)for mMOC patients was 8.4 months(95%CI:5.56-11.32),while the median OS for pMOC patients was not reached(P<0.001).Conclusion Menopausal status,CA125 and CEA levels,tumor size,and immunohistochemical staining expression patterns can effectively distinguish pMOC from mMOC.Early identification of mMOC and adoption of more aggressive treatment strategies may improve its survival outcomes.
NETL
NSTL
万方数据
