The role of E2F transcription factor family in gastrointestinal malignant tumors
E2F2s is an important transcription factor,which is closely related to the occurrence and development of digestive tract tumors.Gastrointestinal malignant tumor is a kind of common malignant tumor,including esophageal cancer,gastric cancer,colorectal cancer,etc.,which seriously threatens people's health.Studies have shown that E2F2s plays a key role in digestive tract tumors.E2F2s regulates cell cycle transition and gene expression,and influences cell proliferation and apoptosis.The abnormal expression of E2F2s is closely related to the occurrence and metastasis of digestive tract tumors.Studies have shown that E2F2s can affect the proliferation and migration ability of tumor cells through a variety of signaling pathways,including Rb signaling pathway,p53 signaling pathway,Wnt/β-catenin signaling pathway,and so on.As an important transcription factor,E2F2s affects the biological behavior of tumor cells by regulating various signaling pathways,providing new targets and strategies for the treatment of gastrointestinal malignant tumor.
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