摘要
自然杀伤(NK)细胞是固有免疫细胞的重要组成部分,在肿瘤治疗领域具有重大潜力.NK细胞不仅可以直接识别卵巢癌细胞、利用强烈的细胞毒性作用杀灭卵巢癌细胞,还可以激活抗肿瘤免疫反应,间接发挥抗癌效应.目前,随着NK细胞过继回输和嵌合抗原受体(CAR)-NK细胞的研究快速发展,NK细胞免疫疗法已成为卵巢癌靶向治疗的重要策略.本文详细介绍了NK细胞的表型、免疫学特征和抗肿瘤机制.同时,从NK细胞过继回输、CAR-NK细胞疗法、抗体依赖细胞毒性(ADCC)途径和NK细胞活性调节等多方面综述了NK细胞免疫疗法在卵巢癌治疗中的最新进展,以期为NK细胞免疫疗法的临床应用提供理论依据.
Abstract
Objective Natural killer(NK)cells are an important component of innate immune cells and have significant potential in the field of tumor therapy.NK cells can not only directly recognize ovarian cancer cells and use their strong cytotoxic effects to kill them,but also activate anti-tumor immune responses,indirectly exerting anti-cancer effects.Currently,with the rapid development of NK cell adoptive reinfusion and chimeric antigen receptor(CAR)-NK cells,NK cell immunotherapy has become an important strategy for targeted treatment of ovarian cancer.Therefore,this article provides a detailed introduction to the phenotype,immunological characteristics,and anti-tumor mechanisms of NK cells.At the same time,the latest progress of NK cell immunotherapy in the treatment of ovarian cancer was reviewed from multiple aspects,including NK cell adoptive infusion,CAR-NK cell therapy,antibody dependent cytotoxicity(ADCC)pathway,and NK cell activity regulation,in order to provide theoretical basis for the clinical application of NK cell immunotherapy.
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