黏液性乳腺癌的诊治进展
Progress in diagnosis and treatment of mucinous breast cancer
王艺璇 1刘宝瑞 2谢丽2
作者信息
- 1. 210009 南京 江苏大学鼓楼临床医学院 南京鼓楼医院肿瘤科
- 2. 210009 南京大学医学院附属鼓楼医院肿瘤科
- 折叠
摘要
黏液性乳腺癌(MBC)是一种少见的特殊类型的乳腺癌,主要发生在绝经后女性,通常在乳腺X光片筛查时发现,部分患者可能表现为可触及的肿块.在组织学上,MBC是一种分化良好的肿瘤,其特征是肿瘤细胞周围存在大量细胞外黏液,根据黏蛋白量将MBC分为纯黏液性乳腺癌(PMBC)或混合黏液性乳腺癌(MMBC).与非特殊类型浸润性导管癌(IDC-NST)相比,MBC基因组更为稳定,预后相对更好.但由于MBC发病率低,目前研究以小样本短期随访为特点,相关指南对其治疗并没有明确建议.由于MBC治疗相关循证医学证据较少,本文就MBC的临床病理、基因组学、预后特征及治疗进展进行综述.
Abstract
Mucinous breast carcinoma(MBC)is a rare and special type of breast cancer,which mainly occurs in postmenopausal women.It is usually found during mammography screening,but some patients may show palpable masses.MBC is a tumor with good histological differentiation,which is characterized by a large amount of extracellular mucus around tumor cells.According to the amount of mucin,MBC can be divided into pure mucinous breast carcinoma(PMBC)or mixed mucinous breast carcinoma(MMC).Compared with non-specific invasive ductal carcinoma(IDC-NST),the MBC genome is more stable and has a relatively better prognosis.However,because of the low incidence rate,the study of MBC is characterized by a small sample or short-term follow-up,and the relevant guidelines have no clear recommendations on its treatment.Due to limited evidence-based medicine evidence of evidence-based medicine related to MBC treatment.This article provides a review of the clinical pathology,genomics,prognostic characteristics,and treatment progress of MBC.
关键词
黏液性乳腺癌/病理特征/预后/基因组学/治疗进展Key words
Mucinous breast cancer/Pathological characteristics/Prognosis/Genomics/Treatment progress引用本文复制引用
出版年
2024
NETL
NSTL
万方数据