This article mainly studies the clinical efficacy of using a combination of esomeprazole and betametha-sone in the treatment of cognitive impairment patients after cerebral infarction,as well as their impact on SOD,IGF-1,and BDNF levels.Fifty patients with cognitive impairment after cerebral infarction admitted to our hospital from January 2021 to December 2022 were selected as the observation subjects.They were randomly divided into an observation group and a control group,with 25 cases in each group.The observation group received treatment with combination of esomeprazole and betamethasone,while the control group received conventional treatment.The clin-ical efficacy,incidence of adverse reactions,serological indicators[superoxide dismutase(SOD),insulin-like growth factor-1(IGF-1),and brain-derived neurotrophic factor(BDNF)],cognitive function[Mini Intelligent Mental State Examination(MMSE),Montreal Cognitive Assessment Scale(MoCA)],and neurological function were compared between the two groups.Norepinephrine(NE),acetylcholine(ACh).The effective rate of the ob-servation group(92%)was better than that of the control group(68%),and the difference was statistically signif-icant(P<0.05);The comparison of neurological function,cognitive function,and serological indicators showed no statistically significant difference between the two groups before treatment(P>0.05).The SOD levels of the two groups decreased after treatment,while the levels of IGF-1 and BDNF increased before treatment.Moreover,the SOD levels of the observation group were lower than those of the control group,while the levels of IGF-1 and BDNF were higher than those of the control group,and the difference was statistically significant(P<0.05);After treatment,the cognitive function scale scores of the two groups increased compared to before treatment,and the MMSE and MoCA of the observation group were higher than those of the control group,with statistical significance(P<0.05);After treatment,the neurological function indicators of the two groups increased compared to before treatment,and the NE and ACh of the observation group were higher than those of the control group,with statistical significance(P<0.05).Conclusion:In the treatment of cognitive impairment after cerebral infarction,the combi-nation of esomeprazole and betamethasone can improve clinical efficacy,improve neurological and cognitive func-tion,and is more helpful in reducing the damage of oxygen free radicals to the human body,improving immune function,and providing protein nutrition to the nerves.It is worth promoting.
AldobenzoquinoneBetamethasonecerebral infarctioncognitive function
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