Given that most existing blood glucose detection methods are invasive tests,the study mentioned by the title was conducted.Poly[2-methoxy-5-(2-ethylhexoxy)-1,4-phenylacetylene](MEH-PPV)microspheres were prepared by the lotion-solvent evaporation method,which had perfect circular boundaries and super smooth surfaces,emitting uniform red fluorescence at 330-380 nm of UV excitation wavelength,with emission peaks at 601 nm and 638 nm.By changing the diameter of the microspheres excited by femtosecond laser at a pump power density of 160 nJ·cm-2,it was found that the effective refractive index(2.04)of the microspheres was consistent with the intrinsic refractive index(1.85)of the MEH-PPV polymer,indicating that laser modulation was caused by the resonance of the spherical whispering gallery cavity,which was beneficial for sensing very small changes at the resonance wavelength with the sensor.Using a self-built gas sensor to detect different volume fractions of acetone gas,the volume fraction of acetone gas within(2.0-4.0)× 10 5 was linearly related to the change Δλ in laser wavelength before and after exposure to acetone gas(the laser wavelength λ0 before exposure was about 621 nm),with detection limit of 9.0×10-8(volume fraction),and the sensor had good selectivity for acetone.The proposed method was used to analyze the exhaled gas of simulated diabetes patients containing 2×10-6(volume fraction,the same below)acetone.The detected amount of acetone was 4.05 times of that in the 2×10-6acetone gas,and 78％of that in the healthy individuals exhale gas.It was shown that the sensor could provide a new method for non-invasive diagnosis of diabetes mellitus.
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