Clinical value of MRI,serum squamous cell carcinoma antigen levels in the diagnosis of lymph node metastasis and parame-trial infiltration in cervical cancer
Objective To investigate the value of pelvic MRI,serum squamous cell carcinoma antigen(SCCA),MRI combined with SCCA in the diagnosis of cervical cancer lymph node metastasis and parametrial infiltration.Methods The clinical data of 169 pa-tients with cervical cancer treated in the Department of Obstetrics and Gynecology of Southwest Medical University from January 2019 to December 2021 were retrospectively analyzed.To analyze the related factors affecting preoperative serum SCCA level,and the value of MRI,serum SCCA and their combination in the diagnosis of lymph node metastasis and parametrial infiltration.Results Multivari-ate analysis showed that late pathological stage,parametrial infiltration,deep muscle invasion,lymph node metastasis,and tumor diameter>4 centimeters were independent risk factors for increased SCCA level(P<0.05).The sensitivity,specificity and accuracy of MRI combined with serum SCCA were 42.8%,97.4%and 92.9%,respectively.The sensitivity,specificity and accuracy of lymph node metastasis were 67.8%,97.1%and 92.3%,respectively.The sensitivity,specificity and accuracy of diagnosis of non-local ad-vanced lymph node metastasis were65.0%,99.2%and94.3%respectively.Conclusion MRI combined with serum SCCA exami-nation has important clinical application value in the diagnosis of lymph node metastasis and parametrial infiltration of cervical squa-mous cell carcinoma,which can provide theoretical basis for evaluating the condition before treatment and making treatment plan.
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