18F-脱氧葡萄糖PET/CT两种评估方法对弥漫性大B细胞淋巴瘤患者化疗中期疗效评估及对预后预测价值
Value of two methods of 18 F-fluorodeoxyglucose PET/CT in the evaluation of interim therapeutic efficacy and prognosis of diffuse large B-cell lymphoma
侯丽杰 1陆国秀 2李妁 3王明丽 1阮超 1郝珊瑚2
作者信息
- 1. 大连医科大学北部战区总医院研究生培养基地,辽宁 沈阳 110016
- 2. 北部战区总医院 核医学科,辽宁 沈阳 110016
- 3. 中国医科大学北部战区总医院研究生培养基地,辽宁 沈阳 110016
- 折叠
摘要
目的 探讨18F-脱氧葡萄糖(18F-FDG)PET/CT中的Deauville五分法、ΔSUVmax法对弥漫性大B细胞淋巴瘤(DL-BCL)患者化疗中期评估效能及对化疗12 个月后的疗效预测价值.方法 回顾性分析自2019 年4 月至2022 年11 月北部战区总医院收治的42 例DLBCL患者的临床资料和影像资料.采用受试者工作特征(ROC)曲线分析ΔSUVmax%判断疗效的最佳截断值.以Lugano评估标准为"金标准",分析Deauville五分法、ΔSUVmax法与Lugano评估标准评价化疗中期疗效的一致性.比较ΔSUVmax法与Deauville五分法的敏感性、特异性.分析Deauville五分法、ΔSUVmax法预测化疗 12 个月后疾病缓解情况.结果 Deauville五分法与Lugano评估标准一致性检验Kappa值为 0.538(P =0.011).ΔSUVmax法与Lugano评估标准一致性检验Kappa值为0.769(P<0.001).ΔSUVmax法敏感性为 83.33%、特异性为 93.33%,分别高于Deauville五分法的50.00%、82.35%,但差异无统计学意义(P>0.05).Deauville五分法:阴性患者 12 个月后完全缓解率为 70.59%(12/34),高于阳性患者的25.00%(2/8),差异有统计学意义(P<0.05).ΔSUVmax法:阴性患者 12 个月后完全缓解率为80.00%(24/30),高于阳性患者的 16.67%(2/12),差异有统计学意义(P<0.05).结论 基于中期PET/CT的视觉分析Deauville五分法和半定量分析ΔSUVmax法对DLBCL患者中期化疗效果评估价值及对化疗 12 个月后的疗效预测价值均较高,且ΔSUVmax法与Lugano评估标准一致性更高.
Abstract
Objective To investigate the efficacy of 18F-fluorodeoxyglucose(18F-FDG)PET/CT Deauville 15-point scale and ΔSUVmax%method in the interim evaluation of chemotherapy in patients with diffuse large B-cell lymphoma(DLBCL)and the value of predicting the curative effect in patients after 12 monthes.Methods The clinical and imaging data of 42 DLBCL patients admitted to General Hospital of Northern Theater Command from April 2019 to November 2022 were retrospectively analyzed.Receiver operating characteristic(ROC)curve analysis was used to classify the optimal cut-off value of ΔSUVmax%for determining the curative effect.Lugano evaluation standard as the"gold standard",the consistency of Deauville 5-point scale method,ΔSUVmax method and Lugano criteria for evaluation of patients'interim chemotherapy treatment was compared.The sensitivity and specificity of ΔSUVmax method and Deauville 5-point scale method were compared.The Deauville 5-point scale method and ΔSUVmax method were analyzed to predict disease remission after 12 months.Results The Kappa value of the consistency test between Deauville 5-point scale and Lugano eval-uation criteria was 0.538(P =0.011).The Kappa value of the consistency test between ΔSUVmax method and Lugano evaluation cri-teria was 0.769(P<0.001).The sensitivity and specificity of ΔSUVmax method were 83.33%and 93.33%,respectively higher than those of Deauville5-point scale(50.00%and 82.35%),but the difference was not statistically significant(P>0.05).Deauville 5-point scale method:the complete remission rate of negative patients was70.59%(12/34)after12 months,which was higher than that of positive patients(25.00%,2/8),and the difference was statistically significant(P<0.05).ΔSUVmax method:the complete remis-sion rate of negative patients after 12 months was 80.00%(24/30),higher than that of positive patients(16.67%,2/12),the differ-ence was statistically significant(P<0.05).Conclusion Mid-term PET/CT based visual analysis Deauville5-point scale and semi-quantitative analysis ΔSUVmax method have higher value in evaluating the efficacy of mid-term chemotherapy in DLBCL patients and predicting the efficacy after 12 months of chemotherapy,and ΔSUVmax method has higher consistency with Lugano standard.
关键词
弥漫大B细胞淋巴瘤/PET/CT/Deauville五分法/ΔSUVmax法Key words
Diffuse large B-cell lymphoma/PET/CT/Deauville 5-point scale/ΔSUVmax method引用本文复制引用
基金项目
辽宁省民生科技计划联合计划项目(2021JH2/10300098)
出版年
2024
NETL
NSTL
万方数据