Correlation of systemic immune inflammation index with clinical features and prognosis of patients with renal carcinoma
Objective To investigate the correlation between systemic immune inflammation index(SII)and clinical features and prognosis of patients with renal carcinoma.Methods The clinical data of 1 030 patients with renal carcinoma admitted to West China Hospital of Sichuan University from September 2008 to December 2013 were retrospectively analyzed.Based on median SII,patients were divided into high SII group(n =515,SII≥381.17)and low SII group(n =515,SII<381.17).The main clinical features of the two groups were compared.Linear correlation of Peason was used to analyze the correlation between SII and tumor size.Receiver oper-ating characteristic(ROC)curve was used to evaluate the predictive value of SII for lymph node metastasis in patients with renal carci-noma.Disease-free survival,tumor-specific survival,and overall survival were analyzed by Kaplan-Meier test.Results There were sta-tistically significant differences in surgical scope,tumor size,T stage,lymph node metastasis,Fuhrman grade,hemoglobin,white blood cells,monocytes,neutrophils,lymphocytes,platelets and SII between two groups(P<0.05).Linear correlation analysis of Peason showed that SII was positively correlated with tumor size(r =0.204,P<0.001).The area under ROC curve for SII prediction of lymph node metastasis in patients with renal cancer was 0.739(95%confidence interval 0.658 to 0.820,P<0.001).Compared with the low SII group,disease-free survival,tumor-specific survival and overall survival in the high SII group were significantly reduced,with statis-tical significance(P<0.001).Conclusion The increase of SII level before operation is related to tumor size,T stage,lymph node metastasis and Fuhrman grade,and is an independent predictor of poor prognosis in patients with renal cancer.
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