动脉瘤性蛛网膜下腔出血患者预后性别差异:倾向性评分匹配分析
Sex difference in prognosis of patients with aneurysmal subarachnoid hemorrhage:matching analysis of propensity score
韩雨薇 1金海 1陈立刚 1郝广志 1霍达 1李晓明 1梁国标1
作者信息
- 1. 北部战区总医院 神经外科,辽宁 沈阳 110016
- 折叠
摘要
目的 探讨动脉瘤性蛛网膜下腔出血(aSAH)患者预后的性别差异.方法 回顾性分析北部战区总医院自2020 年4 月至2022 年1 月收治的665 例aSAH患者的临床资料.采用1∶1 倾向性评分匹配,比较不同性别患者的临床资料,分析预后不良的风险因素.结果 倾向性评分匹配后,女性患者迟发性脑缺血、脑积水、改良Rankin量表评分≥2 分比例高于男性,差异有统计学意义(P＜0.05).年龄、性别、吸烟、Hunt Hess分级Ⅳ～Ⅴ级、mFisher评分 3～4 分、迟发性脑缺血、脑积水是aSAH患者出院3 个月预后不良的独立危险因素(P＜0.05).结论 女性aSAH患者的预后比男性差,这种差异可能与女性患者更易受到迟发性脑缺血和脑积水的影响有关.
Abstract
Objective To investigate the gender difference in prognosis of patients with aneurysmal subarachnoid hemorrhage(aSAH).Methods The clinical data of 665 patients with aSAH admitted to General Hospital of Northern Theater Command from A-pril 2020 to January 2022 were retrospectively analyzed.The clinical data of patients with different genders were compared by 1∶1 pro-pensity score matching,and the risk factors of poor prognosis were analyzed.Results After matching the propensity score,the ratio of delayed cerebral ischemia,hydrocephalus and modified Rankin scale score≥2 points in female patients was higher than that in male patients,and the difference was statistically significant(P＜0.05).Age,sex,smoking,Hunt Hess grade Ⅳ-Ⅴ,mFisher score 3-4,de-layed cerebral ischemia and hydrocephalus were independent risk factors for poor prognosis 3 months after discharge in aSAH patients(P＜0.05).Conclusion The prognosis of female aSAH patients is worse than that of male patients,and this difference may be relat-ed to female patients'higher susceptibility to delayed cerebral ischemia and hydrocephalus.
关键词
动脉瘤性蛛网膜下腔出血/女性/倾向性评分匹配/预后Key words
Aneurysmal subarachnoid hemorrhage/Female/Propensity score matching/Prognosis引用本文复制引用
基金项目
辽宁省应用基础研究计划(2022JH2/101500037)
出版年
2024
NETL
NSTL
万方数据