Analysis of the safety and efficacy of continuous injection of mivacurium chloride during intracranial aneurysm embolization
Objective To investigate the safety and efficacy of continuous injection of mivacurium chloride during intracranial aneu-rysm embolization.Methods A total of 60 patients who underwent intracranial aneurysm embolization from April to October 2023 in General Hospital of Northern Theater Command were selected as the study objects.Patients were divided into mivacurium chloride group(group M)and rocuronium bromide group(group L)by random number table method,with 30 cases in each group.Both groups were given sufentanil 0.20～0.40 μg/kg+propofol 2.00～4.00 mg/kg for anesthesia induction.Group M was given 0.25 mg/kg mivacurium chloride and group L was given 0.60 mg/kg rocuronium bromide.After induction,laryngeal mask was inserted and intraoperative maintenance was maintained in both groups.The group M was continuously injected with 0.3 mg/(kg·h)of miva-curium chloride,and the group L was intermittently injected with 0.2 mg/kg of rocuronium.Plasma histamine concentrations were ob-served before,5 minutes and 15 minutes of administration in the two groups.The changes of airway pressure and circulation were ob-served immediately,15 minutes,30 minutes and 45 minutes after laryngeal mask placement in two groups.The onset time of muscle re-laxation,operation time,removal time of laryngeal mask,occurrence of adverse reactions and operator satisfaction were compared be-tween the two groups.Results The plasma histamine concentrations in group M at 5 minutes and 15 minutes were higher than those in group L,and the differences were statistically significant(P＜0.05).The plasma histamine concentrations of group M at 5 minutes and 15 minutes was higher than that before administration,and the difference was statistically significant(P＜0.05).The airway pressure in group M was lower than that in group L 45 minutes after laryngeal mask placement,and the difference was statistically significant(P＜0.05).There was no significant difference in mean arterial pressure and heart rate immediately,15 minutes,30 minutes and 45 minutes between the two groups after laryngeal mask implantation(P＞0.05).The removal time of laryngeal mask in group M was shorter than that in group L,and the satisfaction of the surgeon was higher than that in group L,the difference was statistically signifi-cant(P＜0.05).There was no significant difference in onset time of muscle relaxation and incidence of adverse reactions between the two groups(P＞0.05).Conclusion Pumping of micuronium chloride during intracranial aneurysm embolization is safe and effective,without serious adverse reactions,and can increase the satisfaction of the surgeon.
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