Effect of paraaortic lymphadenectomy in total hysterectomy of double adnexa in patients with type Ⅰ endometrial cancer
Objective To investigate the effect of para-aortic lymphadenectomy in total double-adnexectomy of endometrial carcinoma type Ⅰ.Methods A total of 91 patients with type Ⅰ endometrial cancer admitted to Affiliated Hospital of Southwest Medical University from January 2016 to March 2018 were selected as the study objects.Patients were divided into group A(n =36,no para-aortic lymph-adenectomy)and group B(n =55,para-aortic lymphadenectomy)according to whether para-aortic lymphadenectomy was performed.The perioperative indexes[carcino-embryonic antigen(CEA),human epididymis protein 4(HE4),cancer antigen 125(CA125),cancer antigen 19-9(CA19-9)]and biochemical indexes[neutrophil/lymphocyte ratio(NLR),D-dimer(D-D)]were compared between the two groups before and after surgery.Results The operation time,the number of lymph node dissection and the length of hospital stay in group B were higher than those in group A,with statistical significance(P<0.05).CEA,HE4,CA125,CA19-9,NLR and D-D were all decreased in two groups after surgery,and group B was lower than group A,with statistical significance(P<0.05).The three-year and five-year survival rates of group B were higher than those of group A,but the difference was not statistically significant(P>0.05).The recurrence rate of group A was higher than that of group B,and the difference was statistically significant(P<0.05).Conclusion Paraaortic lymphadenectomy during total hysterectomy of double adnexes in patients with type Ⅰ endometrial cancer can reduce the level of perioperative indexes,biochemical indexes and recurrence rate.
Type Ⅰ endometrial carcinomaParaaortic lymph node resectionPerioperative periodTumor marker
NETL
NSTL
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