Clinical effect of ultrasonic subgingival curettage combined with tinidazole irrigation on chronic periodontitis and its influ-ence on chemokines,inflammatory factors and matrix metalloproteinases in gingival crevicular fluid
Objective To investigate the clinical efficacy of ultrasonic subgingival curettage combined with tinidazole irrigation in the treatment of chronic periodontitis and its effects on chemokines,inflammatory factors and matrix metalloproteinases(MMPs)in gingival crevicular fluid.Methods A total of 133 patients with chronic periodontal disease admitted to General Hospital of Northern Theater Command from January 2018 to December 2019 were selected as the study objects.Patients were divided into group A(n =67)and group B(n =66)by random number table method.Patients in group A were irrigated with sterile distilled water,and patients in group B were treated with ultrasonic subgingival curettage combined with tinidazole.Before treatment and one month after treatment,the chemo-kines[CX3C chemokine ligand 1(CX3CL1),ligand of receptor activator of NF-κB(RANKL),osteoprotectin(OPG),RANKL/OPG],inflammatory factors[tumor necrosis factor-α(TNF-α),interleukin-1β(IL-1β),interleukin-6(IL-6),interleukin-8(IL-8)],MMPs(MMP-2,MMP-8,MMP-9),periodontal status[tooth mobility(TM),probing depth(PD),sulcus bleeding index(SBI),plaque index(PLI)].The clinical efficacy of the two groups was compared.Results After treatment,CX3CL1,RANKL,RANKL/OPG,TNF-α,IL-1β,IL-6,IL-8,MMP-2,MMP-8,MMP-9,TM,PD,SBI and PLI in two groups were lower than before treatment,and those in group B were lower than those in group A.The differences were statistically significant(P＜0.05).After treatment,OPG in both groups was higher than before treatment,and OPG in group B was higher than that in group A,with statistical significance(P＜0.05).The total ef-fective rate of group B was 90.91%(60/66),higher than 79.10%(53/67)of group A,and the difference was statistically significant(P＜0.05).Conclusion Ultrasonic subgingival curettage combined with tinidazole irrigation is effective in the treatment of patients with chronic periodontitis and can effectively improve their periodontal status.
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