Safety and efficacy of ticagrelor versus clopidogrel in patients with acute coronary syndrome with high body mass index
Objective To compare the safety and efficacy of ticagrelor versus clopidogrel in patients with acute coronary syndrome(ACS)with high body mass index(BMI).Methods A total of 3 140 patients with high BMI with ACS admitted to the Department of Cardiology of General Hospital of Northern Theater Command from March 2016 to March 2019 were selected as the study objects.Pa-tients were divided into clopidogrel group(n=1 877)and ticagrelor group(n=1 263)according to drug use.The bias score matching method was used to adjust the difference between the two groups by 1∶1 matching.The general data,surgical data,drug use after dis-charge,and the occurrence of adverse events were recorded and compared between the two groups before and after propensity score matching.Results Before matching the propensity score,age,left ventricular ejection fraction,hypertension,previous stroke,anemia,cardiac death and all-cause death in clopidogrel group were higher than those in ticagrelor group and the BMI,glomerular filter rate,number of stents,length of stents and male,left main and left anterior descending branches of target vessels,proportion of angiotensin-converting enzyme inhibitors/angiotensin receptor blockers were lower than those in ticagrelor group,with statistical significance(P<0.05).There were significant differences in smoking and coronary heart disease diagnosis types between the two groups(P<0.05).After matching the propensity score,there was no statistical significance in the general information,surgical information and drug use after discharge between the two groups(P>0.05),and the incidence of all-cause death in clopidogrel group was higher than ticagrelor group,and the difference was statistically significant(P<0.05).Conclusion The use of ticagrelor in high BMI patients with ACS can reduce the occurrence of all-cause death.
Acute coronary syndromeBody mass indexPercutaneous coronary interventionClopidogrelTigrillo
NETL
NSTL
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