C-reactive protein and cardiac conduction disorders:a two-sample Mendelian randomization study
Objective To investigate the causal relationship between C-reactive protein(CRP)and cardiac conduction disorders.Methods Single nucleotide polymorphism(SNP)associated with serum CRP concentration were selected as instrumental variables in a genome-wide association study of 204 402 individuals of European ancestry using two-sample mendelian randomization analysis.Ge-netic variants associated with three heart conduction disorders[atrioventricular block(AV-block),left bundle branch block(LBBB),and right bundle branch block]were obtained using pooled data from the FinnGen database(2nd edition).The inverse variance weigh-ting method was used for the main analysis,and then sensitivity analysis,pleiotropy test and remain-one method were used respectively to evaluate the reliability of the results.Results A total of 50 SNPs were included as instrumental variables.Inverse variance weighted analysis showed no significant causal association between genetically predicted serum CRP concentration and cardiac conduction disor-ders,and the results were AV-block(odds ratio 0.983,95%confidence interval 0.820 to 1.177,P=0.849),LBBB(odds ratio 1.201,95%confidence interval 0.911 to 1.583,P=0.194)and RBBB(odds ratio 1.292,95%confidence interval 0.881 to 1.894,P=0.194).Sensitivity analysis showed that CRP was not significantly correlated with atrioventricular block,left bundle branch block and right bundle branch block(P>0.05).Pleiotropy test showed no heterogeneity or pleiotropy between CRP and AV-block,BBB,BB(P>0.05).The remain-one method suggests that removing a single SNP has no significant effect on the results.Conclusion There is no causal relationship between CRP concentration and cardiac conduction disorder.
Mendelian randomizationC-reactive proteinCardiac conduction disordersArrhythmiaCausal association
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