Prognostic value of optimal antiplatelet therapy for Chinese patients with coronary artery disease score in predicting 12-month ischemic event risk in patients with acute coronary syndrome of different genders after discharge
Objective To evaluate the predictive value of optimal antiplatelet therapy for Chinese patients with coronary artery disease(OPT-CAD)score for 12-month ischemic event risk in patients with acute coronary syndrome(ACS)of different genders after dis-charge.Methods A total of 16 343 ACS patients who underwent percutaneous coronary intervention(PCI)from March 2016 to March 2019 in the Department of Cardiology of General Hospital of Northern Theater Command were selected as the study objects.The pa-tients were divided into male group(n=11 947)and female group(n=4 396)according to sex.The primary endpoint event was is-chemic events within 12 months after discharge,including cardiac death,myocardial infarction(MI),and stroke.Secondary endpoint e-vents were independent components of ischemic events and all-cause death within 12 months.Time dependent receiver operator charac-teristic(ROC)curve was used to evaluate the predictive value of OPT-CAD scores for ischemic events at various time points within 12 months after discharge in male and female patients.Results The age,left ventricular ejection fraction,OPT-CAD score and the proportion of hypertension,diabetes and previous stroke in female group were higher than those in male group,and the proportion of previous MI,previous PCI and creatinine clearance were lower than those in male group,with statistical significance(P<0.05).There were statistically significant differences in smoking history and coronary heart disease type between the two groups(P<0.05).The proportion of radial artery puncture in female group was lower than that in male group,and the proportion of left anterior descending branch lesions was higher than that in male group,with statistical significance(P<0.05).The proportion of blockers in female group was higher than that in male group,with statistical significance(P<0.05).The types of P2Y12 antagonists between the two groups were statistically significant(P<0.05).The incidence of cardiac death and all-cause death in female group was higher than that in male group,and the differences were statistically significant(P<0.05).The area under ROC curve(AUC)of male patients at 3,6,9 and 12 months after discharge was 0.77,0.75,0.72 and 0.71,respectively,while the AUC of female patients at 3,6,9 and 12 months after discharge was 0.83,0.78,0.77 and 0.75,respectively.Conclusion The OPT-CAD score can accurately and reliably predict the risk of ischemic events in male and female patients with ACS within 12 months after discharge.
Optimal antiplatelet therapy for Chinese patients with coronary artery diseaseAcute coronary syndromeIschemic eventSex
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