不同运动强度对冠心病患者死亡事件发生风险影响
Effect of different exercise intensity on risk of death events in patients with coronary heart disease
周尚珣 1段一璇 1刘道申 1徐颖 2母雪飞 2祁子钊 2裘淼涵 2李晶 2韩雅玲 2李毅2
作者信息
- 1. 北部战区总医院 心血管内科,辽宁 沈阳 110016;空军军医大学,陕西 西安 710032
- 2. 北部战区总医院 心血管内科,辽宁 沈阳 110016
- 折叠
摘要
目的 探讨不同运动强度对冠心病(CHD)患者死亡事件发生风险的影响.方法 选取国家健康与营养检查调查数据库中2007-2018 年纳入的3 215 例CHD患者为研究对象.根据不同运动强度将患者分为不运动组(n=1 354)、中强度运动组(n=1 230)与高强度运动组(n=631).记录并比较3 组患者的基线资料.采用Kaplan-Meier生存分析对3 组患者的终点事件累计发生率进行描述.应用Cox回归模型分析CHD患者发生全因死亡和心源性死亡的危险因素.结果 中强度运动组、高强度运动组患者白蛋白、男性比例均高于不运动组,年龄、肌酐及贫血、糖尿病、慢性阻塞性肺疾病、全因死亡、心源性死亡、癌症死亡比例均低于不运动组,差异均有统计学意义(P<0.05);3 组患者家庭贫困指数分级、抑郁程度分级比较,差异均有统计学意义(P<0.05).Kaplan-Meier生存曲线显示,高强度运动组全因死亡、心源性死亡发生率均低于不运动组、中强度运动组,差异均有统计学意义(P<0.05).Cox回归分析显示,不运动是CHD患者全因死亡和心源性死亡的独立危险因素(P<0.05).结论 中高强度运动与CHD患者全因死亡及心源性死亡发生风险降低相关.
Abstract
Objective To investigate the effect of different exercise intensity on the risk of death events in patients with coronary heart disease(CHD).Methods A total of 3 215 CHD patients from 2007 to 2018 were selected from the National Health and Nutrition Ex-amination Survey database.The patients were divided into no exercise group(n=1 354),moderate exercise group(n=1 230)and high intensity exercise group(n=631)according to different exercise intensity.The baseline data of the three groups were recorded and compared.Kaplan-Meier survival analysis was used to describe the cumulative incidence of endpoint events in the 3 groups.Cox regres-sion model was used to analyze the risk factors of all-cause death and cardiac death in CHD patients.Results Albumin level and male ratio in the moderate exercise group and the high intensity exercise group were higher than those in the no exercise group,age,creati-nine,and the proportions of anemia,diabetes,chronic obstructive pulmonary disease,all-cause death,cardiac death and cancer death were lower than those in the no exercise group,with statistical significance(P<0.05).There were significant differences in family pov-erty index and depression degree among 3 groups(P<0.05).Kaplan-Meier survival curve showed that the incidence of all-cause death and cardiac death in the high intensity exercise group was lower than that in the no exercise group and the moderate intensity exercise group,and the differences were statistically significant(P<0.05).Cox regression analysis showed that inactivity was an independent risk factor for all-cause death and cardiogenic death in CHD patients(P<0.05).Conclusion Moderate to high intensity exercise is associated with a reduced risk of all-cause death and cardiac death in patients with CHD.
关键词
冠心病/运动强度/全因死亡/心源性死亡Key words
Coronary heart disease/Exercise intensity/All-cause death/Cardiac death引用本文复制引用
基金项目
国家重点研发计划(2022YFC2503500)
国家重点研发计划(2022YFC2503504)
出版年
2024
NETL
NSTL
万方数据