Identification of common differentially expressed genes in gastric cancer and liver cancer through bioinformatics analysis
Objective To explore the differentially expressed genes in gastric cancer and liver cancer,and analyze their biological functions and potential value in clinical application.Methods Gastric cancer related dataset GSE79943 and liver cancer related data-set GSE84402 were selected for analysis in the comprehensive gene expression database.Through differential analysis of gene expres-sion data from the two datasets,the common differentially expressed genes were identified,and the main biological functions and path-way participation of the differentially expressed genes were further revealed by GO enrichment and KEGG enrichment analysis.Results A total of 117 genes were identified that were differentially expressed in gastric cancer and liver cancer.GO enrichment anal-ysis software was used to analyze 117 genes and found that these genes play a crucial role in the occurrence and transport of a variety of metal ions and inorganic substances,such as copper,zinc,calcium ions,and cell metabolism of inorganic substances.KEGG enrich-ment analysis software was used to analyze the gene functions of 117 differential genes,and it was found that more of these genes played the functions of inorganic matter absorption and metabolism.By analyzing the results of GO and KEGG enrichment analysis,eight major genes closely related to the metabolism of inorganic substances were obtained,namely MT1G,MT2A,MT1E,MT1X,MT1F,MT1H,MT1M and MT1HL1,which had significantly low expression in both diseases.Conclusion Through the differential analysis of gene expression data of gastric cancer and liver cancer,revealed the common differential expression of gene groups in these two canc-ers,and found their important roles in the metabolism of inorganic substances.These differential genes may be involved in regulating the absorption and metabolism of metal ions by tumor cells,thus affecting the development of tumors,and can be used as potential ther-apeutic targets and prognostic indicators for gastric and liver cancer.
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