Clinical effect of Qijiaoshengbai capsule on toxic diffuse goiter complicated with leukopenia
Objective To investigate the clinical effect of Qijiaoshengbai capsule in the treatment of graves disease(GD)complicated with leukopenia.Methods A total of 128 patients with GD combined with leukopenia admitted to the General Hospital of Northern Theater Command from January 2018 to November 2021 were selected as the study objects.According to different treatment methods,the patients were divided into group A and group B,64 cases in each group.Patients in group A were treated with conventional antithy-roid drugs plus white blood cell(WBC)elevation therapy.The patients in group B were treated with conventional antithyroid drugs Qi-jiaoshengbai capsule.The cure rate and effective rate of the two groups were compared.The levels of WBC,free triiodothyronine(FT3),free thyroxine(FT4),thyroid stimulating hormone(TSH),thyroid stimulating hormone receptor antibodies(TRAb)and goiter in the two groups were recorded and compared before and 1,3 and 6 months after treatment,respectively.The occurrence of adverse re-actions was recorded in the two groups.Results The cure rate of group A was 75.00%(48/64),lower than that of group B(89.06%,57/64),the difference was statistically significant(P<0.05).The effective rate of treatment in group A and group B was 92.19%(59/64)and 93.75%(60/64),respectively,with no statistical significance(P>0.05).At 1,3 and 6 months after treat-ment,WBC in group B was higher than those in group A,and FT3 and TRAb were lower than those in group A,with statistical signifi-cance(P<0.05).At 3 and 6 months after treatment,FT4 and TSH in group B were lower than those in group A,with statistical signif-icance(P<0.05).Compared with before treatment,WBC and TSH were increased in group A and group B at 1,3 and 6 months after treatment,while FT3,FT4,TRAb and goiter degree were decreased,with statistical significance(P<0.05).During treatment and 6-month follow-up,no significant adverse reactions occurred in both groups.Conclusion Qijiaoshengbai capsule can effectively increase the level of WBC and improve the level of GD related indexes,and can be used for the treatment of GD patients with leukopenia
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