Effect of ticagrelor on cardiopulmonary function in patients after percutaneous coronary intervention
Objective To investigate the cardiopulmonary function changes in patients after percutaneous coronary intervention(PCI)with ticagrelor.Methods A total of 3 800 patients with coronary heart disease who underwent PCI at General Hospital of Northern Theater Command from November 2015 to September 2021 and completed cardiopulmonary exercise test(CPET)before discharge were included in the study.Patients were divided into the non-ticagrelor group(n=2 574)and the ticagrelor group(n=1 226)ac-cording to whether or not they were using ticagrelor.Propensity score was used to match the two groups by sex,age,body mass index,previous PCI and old myocardial infarction.Demographic information,past medical history,laboratory results,medication history,and CPET related indicators were collected and compared between the two groups before and after matching.Results After matching,there were 1 192 patients in each group.Before matching,the body mass index,heart rate,hemoglobin,N-terminal B-type natriuretic peptide(NT-proBNP),male,smoking history,drinking history,previous PCI and old myocardial infarction in ticagrelor group were higher than those in non-ticagrelor group,with statistical significance(P<0.05).Age,total cholesterol,systolic blood pressure,left ventricular ejection fraction and stroke history ratio were all lower than those in non-ticagrelor group,with statistical significance(P<0.05).After matching,the heart rate,NT-proBNP and creatine kinase isoenzyme in ticagrelor group were higher than those in non-ti-cagrelor group,and left ventricular ejection fraction and hemoglobin were lower than those in non-ticagrelor group,with statistical sig-nificance(P<0.05).Before matching,the anaerobic threshold oxygen uptake and anaerobic threshold metabolic equivalent in ti-cagrelor group were lower than those in non-ticagrelor group,and the peak oxygen pulse,heart rate reserve and peak diastolic blood pressure during exercise were higher than those in non-ticagrelor group,with statistical significance(P<0.05).After matching,the peak oxygen uptake,anaerobic threshold oxygen uptake,peak metabolic equivalent,anaerobic threshold metabolic equivalent and peak oxygen pulse in ticagrelor group were lower than those in non-ticagrelor group,with statistical significance(P<0.05).Conclusion The cardiopulmonary function of patients after PCI using ticagrelor is relatively poor.
Coronary artery diseasePercutaneous coronary interventionTicagrelorCardiopulmonary exercise test
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