首页|循环炎症因子水平与辐射相关皮肤及皮下组织疾病双向孟德尔随机化分析

循环炎症因子水平与辐射相关皮肤及皮下组织疾病双向孟德尔随机化分析

扫码查看
原文链接
  • NETL
  • NSTL
  • 万方数据
目的 探讨循环炎症因子水平与辐射相关皮肤和皮下组织疾病(RRDST)之间的因果关系。方法 基于全基因组关联研究数据，采用5 种孟德尔随机化(MR)方法分析血清中70 种循环炎症因子水平与RRDST的关系。结果 正向MR结果显示，嗜酸性粒细胞趋化因子(CCL11)(比值比=0。941 8，95%可信区间 0。891 0～0。995 5，P=0。034 1)、趋化因子(CX-CL)10(比值比=0。929 5，95%可信区间0。881 9～0。979 7，P=0。006 5)、骨保护素(OPG)(比值比=0。868 3，95%可信区间0。774 9～0。973 0，P=0。015 0)与RRDST之间存在显著负相关，CXCL6(比值比=1。108 2，95%可信区间1。036 1～1。185 3，P=0。002 8)、白细胞介素(IL)-15 受体α(比值比=1。080 0，95%可信区间1。022 8～1。140 4，P=0。005 5)、白血病抑制因子受体(LIFR)(比值比=1。073 4，95%可信区间 1。014 6～1。135 7，P=0。013 8)、单核细胞趋化蛋白(MCP-1)(比值比=1。092 8，95%可信区间1。035 0～1。153 8，P=0。001 4)、硫酸氨基转移酶(SULT)1A1(比值比=1。0665，95%可信区间1。0054～1。131 3，P=0。032 4)与RRDST之间存在显著正相关;敏感性分析证实了这些因果关系的稳健性;反向MR分析未发现RRDST与循环炎症因子水平存在显著的反向因果关系。结论 正向和反向MR分析揭示了特定炎症因子水平与RRDST风险之间的显著因果关系，CCL11、CXCL10、OPG水平与RRDST风险显著负相关，而CXCL6、IL-15 受体α、LIFR、MCP-1、SULT1A1 水平与RRDST风险显著正相关。这些发现为理解RRDST的病理机制提供了新的见解，并为未来的临床和公共卫生干预措施提供了潜在的目标。
Bidirectional Mendelian randomized analysis of circulating inflammatory factor levels and radiation-related skin and subcu-taneous tissue diseases
Objective To investigate the causal relationship between levels of circulating inflammatory factor levels and radiation-re-lated skin and subcutaneous tissue diseases(RRDST).Methods Based on Genome Wide Association Study data,five Mendelian ran-domization(MR)methods were used to analyze the relationship between serum levels of 70 circulating inflammatory factors and RRDST.Results Positive MR results showed that CC chemokine ligand 11(CCL11)(odds ratio=0.941 8,95%confidence interval 0.891 0-0.995 5,P=0.034 1),chemokines(CXCL)10(odds ratio=0.929 5,95%confidence interval 0.881 9-0.979 7,P=0.006 5),os-toeprotegerin(OPG)(odds ratio=0.868 3,95%confidence interval 0.774 9-0.973 0,P=0.015 0)were significantly negatively cor-related with RRDST,CXCL6(odds ratio=1.108 2,95%confidence interval 1.036 1-1.185 3,P=0.002 8),interleukin(IL)-15 re-ceptor α(odds ratio=1.080 0,95%confidence interval 1.022 8-1.140 4,P=0.005 5),leukemia inhibitory factor receptor(LIFR)(odds ratio=1.073 4,95%confidence interval 1.014 6-1.135 7,P=0.013 8),monocyte chemoattractant protein-1(MCP-1)(odds ratio=1.092 8,95%confidence interval 1.035 0-1.153 8,P=0.001 4),sulfotransferase(SULT)1A1(odds ratio=1.066 5,95%confidence interval 1.005 4-1.131 3,P=0.032 4)were positively correlated with RRDST.Sensitivity analysis confirmed the robust-ness of these causal relationships.Reverse MR analysis did not find a significant reverse causal relationship between RRDST and circu-lating inflammatory factor levels.Conclusion Forward and reverse MR analysis revealed a significant causal relationship between the levels of specific inflammatory factors and the risk of RRDST.CCL11,CXCL10 and OPG levels are significantly negatively correlated with the risk of RRDST.The levels of CXCL6,IL-15 receptor α,LIFR,MCP-1 and SULT1A1 are significantly positively correlated with the risk of RRDST.These findings provide new insights into understanding the pathological mechanisms of RRDST and provide poten-tial targets for future clinical and public health interventions.

Mendelian randomizationCirculating inflammatory factorRadiation-related skin and subcutaneous tissue disea-sesGenome Wide Association Study

杨得富、尚峰、徐莹、阎英

展开 >

北部战区总医院 放射治疗科,辽宁 沈阳 110016

孟德尔随机化 循环炎症因子 辐射相关皮肤和皮下组织疾病 全基因组关联分析

辽宁省科技计划联合计划

2023JH2/101700111

2024

10.16680/j.1671-3826.2024.09.02

临床军医杂志
解放军沈阳军区卫生人员训练基地

临床军医杂志

CSTPCD
影响因子：0.465
ISSN：1671-3826
年,卷(期)：2024.52(9)