Dendritic cells regulate natural killer T cell related pathways after myocardial infarction
Objective To analyze the possible pathways of dendritic cell regulation natural killer T cells after myocardial infarction.Methods Single-cell Selplg-Sell pathway data from a mouse model of myocardial infarction were retrieved using the public ArrayEx-press database,and then dendritic cells were analyzed at the transcriptional level for the regulatory network after myocardial infarction by bioinformatics methods,so as to further identify their pathways for regulating natural killer T cells.Results Through clustering a-nalysis of single-cell sequencing data at different time points in the mouse model,a total of 7 immune cells were identified:neutrophils,monocytesⅠ and Ⅱ,B cells,macrophages,natural killer T cells and Dendritic cells.Intercellular communication analysis and ligand pair analysis confirmed that dendritic cells regulate the infiltration of natural killer T cells after myocardial infarction mainly through the Selplg-Sell pathway.Conclusion Dendritic cells play an important role in immunomodulation after myocardial infarction and regu-late the infiltration of natural killer T cells through the Selplg-Sell pathway.
Myocardial infarctionDendritic cellNatural killer T cellSingle-cell sequencingSelplg-Sell pathway
万方数据
维普
