Analysis of influencing factors of tumor recurrence in patients with periampullary carcinoma after radical resection
Objective To investigate the influencing factors of tumor recurrence in patients with periampullary carcinoma after radical resection.Methods A total of 261 patients with periampullary carcinoma admitted to Anhui Cancer Hospital from January 2017 to A-pril 2024 were selected as the study objects.All patients underwent radical resection.Patients were divided into non-recurrence group(n=165)and recurrence group(n=96)according to whether the tumor recurred during follow-up.The tumor characteristics,laboratory test indexes,lipid metabolism indexes and tumor markers of the two groups were recorded and compared.Multivariate Logistic regres-sion analysis was used to screen the influencing factors of tumor recurrence in patients with periampullary carcinoma after radical re-section.Results There was statistical significance in the differentiation degree between two groups(P＜0.05).The proportion of nerve invasion and vascular cancer thrombus in recurrent group was higher than that in non-recurrence group,and the differences were statistically significant(P＜0.05).There was no significant difference in laboratory test indexes and lipid metabolism indexes between two groups(P＞0.05).The levels of carcinoembryonic antigen(CEA)and carbohydrate antigen 199(CA199)in patients with recur-rence were higher than those in non-recurrence group,and the differences were statistically significant(P＜0.05).Multivariate Logistic regression analysis showed that CEA,CA199,vascular cancer thrombus and nerve invasion were all factors affecting tumor recurrence after radical resection in periampullary carcinoma patients(P＜0.05).Conclusion The level of tumor markers CEA and CA199 is high,and vascular cancer embolus and nerve invasion are independent risk factors for tumor recurrence in patients with periampullary cancer after radical resection.In clinical practice,close attention should be paid and individualized adjuvant therapy should be devel-oped to reduce the risk of tumor recurrence and improve the prognosis of patients.
万方数据
维普
