The relationship between neutrophil-lymphocyte ratio,platelet-lymphocyte ratio,lymphocyte-monocyte ratio and postopera-tive delayed intestinal paralysis in patients with radical colorectal cancer
Objective To investigate the relationship between neutrophil-lymphocyte ratio(NLR),platelet-lymphocyte ratio(PLR),lymphocyte-monocyte ratio(LMR)and delayed intestinal paralysis(PPOI)in patients with radical colorectal cancer after surgery.Methods The clinical data of 98 patients with radical colorectal cancer treated in Xiamen University Affiliated Success Hospital from January 2021 to December 2023 were retrospectively analyzed.Patients were divided intono PPOI group(n=77)and PPOI group(n=21)according to whether they had PPOI or not.The general data and laboratory indicators[white blood cell count(WBC),lym-phocyte count(LYM),monocyte count(MONO),neutrophil count(NEU),platelet count(PLT),NLR,PLR,and LMR levels]of the two groups were compared.Binary Logistic regression model was used to analyze the risk factors of PPOI in postoperative patients with radical colorectal cancer,and receiver operating characteristic(ROC)curve was drawn to analyze the predictive value of NLR,PLR and LMR levels in postoperative PPOI.Results The proportion of patients with tumor diameter greater than or equal to 5 centimeters and the levels of MONO,NEU,PLT,NLR and PLR in PPOI group were higher than those in no PPOI group,and the levels of LMR were lower than those in no PPOI group,with statistical significance(P＜0.05).Binary Logistic regression analysis showed that tumor diameter greater than or equal to 5 centimeters,NLR greater than the median level,PLR greater than the median level,and LMR less than the median level were all risk factors for PPOI in postoperative patients with radical colorectal cancer(P＜0.05).The area under the curve of NLR,PLR,LMR and their combined prediction of postoperative PPOI in patients with radical colorectal cancer were 0.872,0.852,0.887,0.888,and sensitivity were 0.857,0.857,0.857,0.810,respectively,and the specificities were 0.753,0.776,0.831 and 0.870,respectively,all of which had high predictive efficacy(P＜0.05).Conclusion The occurrence of PPOI in patients with radical colorectal cancer after surgery is related to tumor diameter,NLR,PLR and LMR levels.High levels of NLR,PLR and low levels of LMR may increase the risk of PPOI in patients with radical colorectal cancer after surgery.Clinically,the occurrence of PPOI in patients can be predicted by detecting the levels of NLR,PLR and LMR.
Radical colorectal cancerPostoperationProlonged postoperative ileusNeutrophil-lymphocyte ratioPlatelet-lymphocyte ratioLymphocyte-monocyte ratio
万方数据
维普
