Study on the Mechanisms of Alkaloid Components in the Root of Stephania Tetrandra in Preventing and Treating Alzheimer's Disease——Based on Network Pharmacology and Molecular Docking
In this paper,based on network pharmacology and molecular docking methods,it explored the mechanism of the main alkaloid components in the root of Stephania tetrandra against Alzheimer's disease(AD).A total of 6 main alkaloid components were searched in the pharmacology database and analysis platform of traditional Chinese medicine system(TCMSP).The related targets of alkaloids and AD were found in Swiss Target Prediction databases and Disgenet databases.The intersection targets were obtained in Venny 2.1.0 platform,and the protein interaction network was drawn by STRING database.The Kyoto encyclopedia of genes and genomes(KEGG)pathway was analyzed by DAVID database,and the"component-action pathway-action target-disease"network was drawn in Cytoscape 3.9.0 software.Discovery Studio software was used to verify the molecular docking results of six alkaloid components and the main target proteins of anti-AD.The results showed that the main 6 alkaloid components in the root of Stephania tetrandra were related to 47 core targets of AD,and may play a role through 34 related pathways.Among them,the alkaloid components with large degrees include Magnoflorine,Tetrandrine,Menisperine,etc.Key targets include mitogen-activated protein kinase 1(MAPK1),mitogen-activated protein kinase kinase 1(MAP2K1),serine/threonine kinase 1(AKT1),etc.The main pathways include MAPK1 signaling pathway,calcium signaling pathway,phosphoinositide 3-kinase-Akt(PI3K-Akt)signaling pathway,neuroactive ligand-receptor interaction,etc.The above results show that the main alkaloid components in the root of Stephania tetrandra have the characteristics of"multi-component,multi-target and multi-pathway"in the prevention and treatment of AD,which provides a theoretical basis for future research on the mechanism of the main alkaloid components in the root of Stephania tetrandra in the prevention and treatment of AD.
network pharmacologymolecular dockingalkaloid components in the root of Stephania tetrandraAlzheimer's disease
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