A"strong hydrogen bond"is a kind of interaction that possesses the strength between hydrogen bond and covalent bond.The study of"short,strong"or"low barrier"hydrogen bonds has been a topic of interest since the structures of[HX2]-and[HXY]-were found to feature strong hydrogen bonding characteristics in 1968.In this paper,the electronic structure of strong hydrogen bond and its applications in biology,chemistry and material design were reviewed.In the end of the article,the future development of strong hydrogen bond in molecular design was prospected.
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