Study on Synthesis Process of(Z)-2-(furan-2-yl)-2-(methoxyimino)acetic Acid
(Z)-2-(furan-2-yl)-2-(methoxyimino)acetic acid was synthesized by 2-acetylfuran as the starting material with yield of 86%.The optimal oximation reaction conditions were as follows:methoxylamine hydrochloride was 1.8 eq,pH of reaction mixture was 3.0,temperature was 10℃,time was 10 h,conversion was 99.13%,and selectivity of Z-configuration was 92.63%.Degradation of(Z)-2-(furan-2-yl)-2-(methoxyimino)acetic acid followed first-order reaction kinetics,and the lower the pH,the faster the degradation.
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