In order to improve the quality and yield of products by finding out the optimal technological condition,in the green environmental protection solvent dimethyl carbonate,TDA was synthesized by condensation reaction with the side chain compound 2-mercapto-5-methyl-1,3,4-thiadiazole(MMT)and 7-amino-cephalosporanic(7-ACA),so as to increase the yield and quality of TDA.The results showed that the use of dimethyl carbonate with less pollution and easy recovery as the reaction solvent was in line with the requirements of environmental protection and safety production,and the collection rate of TDA was increased from 90%to 120%.The method is an appropriate industrialized method for synthesizing cefazolin intermediates.
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