Research Progress in Asymmetric Catalytic Construction of Axially Chiral Compounds
Most of the natural products and chiral drug molecules with important physiological activities contain axial chiral skeletons,and it is of great practical significance to study how to construct axial chiral compounds and apply them to the efficient synthesis of chiral drugs and natural products.In this paper,the research progress of biaryl,heteroaryl,and other types of axial chiral compounds was discussed,and the asymmetric catalytic synthesis strategies of axial chiral compounds were introduced,and the potential application value of the obtained axial chiral compounds was illustrated by examples.
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