With the development of DNA chemical modification technology,amphiphilic DNA organic compounds are synthesized by solid phase reaction between hydrophobic molecules and DNA.Amphiphilic organic compounds can be regarded as new building blocks and then spontaneously assembled into various nanostructures in solution.The assemblers have important applications in drug delivery,targeted delivery and biosensing.In this paper,the assembly and synthesis of DNA-organic molecules were discussed,as well as the research progress in biomedicine.