Flavonoids play a pivotal role in clinical treatment,health care and other fields,and are a class of star molecules sought after by the industry.Oxa-Michael addition reaction is widely used in the construction of C—O bonds,and it can effectively build rings in intramolecular reactions.From the above two perspectives,the research progress of constructing flavonoid skeleton compounds from 2-hydroxy chalcone substrate and 2-hydroxy alkynyl ketone substrate by intramolecular Oxa-Michael reaction was summarized.The advantages and disadvantages of each catalytic method were compared and analyzed,and the future synthesis methods were prospected.
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