Preparation and Antibacterial Properties of Sulfadiazine Loaded Polyethylene Glycol Prodrugs
Using polyethylene glycol(PEG)with different molecular weights and monochloroacetic acid as raw materials,chloroacetyl polyethylene glycol ester was synthesized by esterification,and PEG-SD prodrugs with different molecular weights were prepared by combining it with sulfadiazine(SD),and were characterized by IR,NMR and UV.The results showed that sulfamethoxazole was successfully loaded onto the end of the polyethylene glycol chain.As the molecular weight of polyvinyl alcohol decreased,its esterification degree increased and the proportion of negative SD increased.Hydrolysis experiments showed that PEG-SD prodrug had a long-lasting sustained-release antibacterial function.As the molecular weight decreased,the antibacterial effect became better.The minimum inhibitory concentrations of PEG600-SD against Escherichia coli and Staphylococcus aureus were 31.25 μg·mL-1 and 15.62 μg·mL-1,respectively,it had the best antibacterial effect.
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