Research Progress in Reaction of Benzoic Acid Derivatives with Olefins
The C—H bond activation reaction assisted by the directing group overcomes the disadvantage of the need for pre-functionalization of the starting material in conventional cross-coupling reactions.Among many guide groups,the carboxyl group is considered as a traceless guide group due to its easy conversion and removal.Indone,phthalide obtained by the reaction of carboxylic acids with olefins are the basic structural units of bioactive molecules and drug molecules,so this kind of reaction has great synthetic significance.In this paper,the reactions between benzoic acid derivatives and olefins catalyzed by different transition metals in the last three decades were described.
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