Cupric Acetate-Catalyzed Cycloaddition Reaction of Azomethine Imines
Pyrazolinone heterocycles have significant applications in biological and material fields.In this study,the 1,3-dipolar cycloaddition reaction of azomethine imine compounds and terminal alkynes was achieved by using cupric acetate as catalyst,2-aminophenol as ligand,and dichloromethane as solvent.The reaction showed high productivity,speed,selectivity,condition mildness,simplicity of operation,and insensitivity to water and air.The catalyst and ligand were stable and easily accessible.Compared to existing literatures,the method adopted in this paper used mild conditions in an open system at room temperature,without glove box operation and oxygen isolation,and at the same time the reaction rate was greatly improved,which complements and develops the existing conditions.
万方数据
维普
