间充质干细胞外泌体治疗玫瑰痤疮的疗效观察
Clinical observation on the therapeutic efficacy of mesenchymal stem cell-derived exosomes for rosacea
周佳 1尹敏 1刘翔 1麦跃 1吴姗姗 1何加炜 1李苗苗 1李帅华 1周欢 1殷珊 1易丽萍 1何琪蕾 1李沛徽 1易雷1
作者信息
- 1. 长沙美莱医疗美容医院,湖南 长沙 410000
- 折叠
摘要
目的 探讨间充质干细胞外泌体(MSC-exo)治疗玫瑰痤疮患者的效果.方法 纳入2021年1月至2022年1月在长沙美莱医疗美容医院皮肤科就诊并确诊为玫瑰痤疮的患者78例,其中丘疹脓疱型(PPR)39例,红斑毛细血管扩张型(ETR)39例.两组患者均接受微针导入MSC-exo治疗,每月1次,共3个月.观察并比较两组红斑评估量表(CEA)、研究者整体评估(IGA)得分、皮肤屏障功能指标、患者自我评估(PSA)、临床疗效及不良反应率等.结果 治疗3次后,与治疗前比较,两组CEA和IGA评分均明显降低,红斑指数(EI)、经皮失水量(TEWL)均明显降低,角质层含水量明显上升,差异均有统计学意义(均P＜0.05).治疗后,PPR组患者CEA评分、IGA评分低于ETR组(均P＜0.05);EI、TEWL评分低于ETR组,角质层含水量高于ETR组(均P＜0.05);PSA评分高于ETR组(P＜0.05);临床有效率高于ETR组(89.74％比64.10％,x2=7.22,P=0.007).两组不良反应发生率无统计学差异(x2=1.92,P=0.166).结论 多次MSC-exo治疗能够显著改善玫瑰痤疮患者皮肤状况,改善皮肤屏障功能.与ETR患者相比,MSC-exo治疗对PPR患者具有更好的临床疗效.
Abstract
Objective To observe the therapeutic effects of mesenchymal stem cell-derived ex-osomes on rosacea.Methods Seventy-eight patients with rosacea,including 39 PPR type and 39 ETR type,were enrolled at the Changsha Mylike Cosmetic Hospital from January 2021 to January 2022.All patients were treated with microneedling infusion of mesenchymal stem cell-derived exo-somes(MSC-exo)once a month for three months.The clinical efficacy,adverse reactions,ery-thema assessment scale(CEA),patient physical evaluation(PSA),investigators'global assess-ment(IGA)scale and skin barrier function were compared between the two groups.Results Treatment with MSC-exo significantly decreased both CEA and IGA scales,EI and TEWL,while increasing stratum corneum hydration(P＜0.05 for all).After 3 treatments with MSC-exo,both CEA and IGA scales were higher in patients with ETR type than in that with PPR type(both P＜0.05).Both EI and TEWL were lower in patients with PPR than in that with ETR(P＜0.05).In contrast,both stratum corneum hydration levels and PSA were higher in patients with PPR than in that with ETR(P＜0.05).The effective rates in patients with PPR type and ETR type were 89.74％and 64.10％,respectively(x2=7.22,P=0.007).However,the adverse reaction rates were comparable between the two groups(x2=1.92,P=0.166).Conclusions Treat-ments with MSC-exo can significantly improve the skin condition and skin barrier function in pa-tients with rosacea.Compared with the ETR group,MSC-exo is more effective in improving skin condition in the PPR.
关键词
玫瑰痤疮/间充质干细胞/外泌体/皮肤屏障/微针Key words
rosacea/mesenchymal stem cell/exosomes/skin barrier/microneedle引用本文复制引用
出版年
2023
国家科技期刊平台
NSTL
维普
万方数据