修护舒缓功效性护肤品在改善敏感肌中的应用:基于60例队列研究
Application of tone repair skincare product in the improvement of sensitive skin:Based on a cohort study of 60 cases
廖志刚 1文思 2冼雪松 2王北明 1龚俊瑞 1张柏慧 2梁锦茵 2傅小晏 2叶理2
作者信息
- 1. 广东华润顺峰药业有限公司,广东 佛山 528300
- 2. 南方医科大学皮肤病医院,广东 广州 510091
- 折叠
摘要
目的 探究修护舒缓功效性护肤品在改善敏感肌中发挥的作用.方法 通过乳酸刺痛试验筛选敏感肌受试者60例,随机分为试验组和对照组各30例,试验组以涂擦修护舒缓功效性护肤品为干预措施,对照组不进行任何干预.检测试验组使用护肤品后2 h及连续使用28 d对皮肤角质层含水量、经皮水分丢失(TEWL)、皮肤红区a*值、红区面积占比、临床评估及受试者自评等指标的改善,并与对照组进行比较.结果 与对照组相比,试验组使用修护舒缓功效性护肤品28 d后可有效改善乳酸刺痛评分,提升皮肤耐受性(Z=-2.83,P＜0.05).使用护肤品2 h及持续使用28 d后,试验组角质层含水量均显著高于对照组(均P＜0.05);使用护肤品28 d后,试验组TEWL显著低于对照组(P＜0.05).使用2 h后,试验组皮肤红区a*值与使用前的差值及变化率均显著低于对照组(均P＜0.05),皮肤红区面积占比与使用前的差值显著低于对照组(t=-2.27,P＜0.05),但28 d后两组皮肤红区a*值与使用前的差值及变化率、皮肤红区面积占比与使用前的差值及变化率间的差异均无统计学意义(均P＞0.05).研究者评价中试验组皮肤干燥、鳞屑、红血丝、紧绷等指标改善情况显著优于对照组(均P＜0.05).结论 修护舒缓功效性护肤品可通过改善皮肤屏障状态发挥功效,可在改善敏感性皮肤的生理状态、日常皮肤屏障保护等方面发挥作用.
Abstract
Objective To explore the role of functional skincare products in improving sensi-tive skin.Methods A total of 60 subjects with sensitive skin were selected by lactic acid sting test and randomly divided into the treated and control groups,30 subjects per group.The treated group used tone repair skincare product and the untreated group served as the controls.The im-provements in skin hydration,transepidermal water loss,a*value,redness area,and investiga-tors'and subjects'self-evaluation scores were compared between the two groups 2 hours and 28 days after the applications.Results Compared to the control group,28-day applications of tone repair skincare product significantly improved lactic acid sting scores(Z=-2.83,P＜0.05).The stratum corneum hydration levels were increased both 2 hours and 28 days after topical appli-cations of the products.In contrast,transepidermal water loss rates were dramatically decreased after 28-day applications(P＜0.05,vs.controls).Both a*value and proportion of redness area were markedly decreased 2 hours after application of the product(P＜0.05 for both).However,no significant differences in a*value and proportion of redness area were observed between the treated and control groups after 28-day applications.The investigators'assessment showed signifi-cant improvements in sensitive skin symptoms and sign,such as dryness,scales,telangiectasia and skin tightness in the treatment group compared to the control group(P＜0.05).Conclusions Functional skincare products can improve the skin barrier function,playing an important role in improving the physiological state of sensitive skin.
关键词
功效性护肤品/皮肤屏障功能/敏感肌/修护Key words
functional skincare products/skin barrier function/sensitive skin/repair引用本文复制引用
基金项目
南方医科大学皮肤病医院-华润三九联合实验室华润顺峰基金重点项目(HR202103)
南方医科大学皮肤病医院-华润三九联合实验室华润顺峰基金苗圃项目(HR202110)
出版年
2023
国家科技期刊平台
NSTL
维普
万方数据