复合中层酸联合30％超分子水杨酸治疗黄褐斑的临床效果
Efficacy of compound middle-layer acid combined with 30％supramolecular salicylic acid for melasma
孙钰 1叶聪秀 1付佼佼 2陈欣玲 1周峰 1蒋雨含 1赖维 1郑跃1
作者信息
- 1. 中山大学附属第三医院,广东 广州 510630
- 2. 广州莱德璞检测技术有限公司,广东 广州 510000
- 折叠
摘要
目的 评估复合中层酸联合30％超分子水杨酸对黄褐斑的治疗效果.方法 选取中山大学附属第三医院2022年5-12月收治的5例女性黄褐斑患者,采用自身平行对照研究.试验侧在第0周与第4周使用复合中层酸,第8周使用30％超分子水杨酸.对照侧在第0周与第4周使用30％超分子水杨酸,第8周使用复合中层酸.评估患者面部皮损面积、颜色、油脂、含水量的情况及患者心理影响程度,综合评估联合方法的疗效.结果 治疗后,试验侧额部、颊部及下颌黄褐斑的面积评分分别由4.00降至3.40、4.60降至4.20、2.20降至2.00(均P＜0.05),对照侧仅额部评分下降;试验侧及对照侧额部、颊部、下颌皮损颜色评分均下降,且试验侧额部、颊部皮损颜色的降幅均显著高于对照侧(P＜0.05);试验侧及对照侧的皮肤油脂均显著升高,试验侧的提升高于对照组(P＜0.05);两侧皮肤含水量均呈升高趋势,试验侧由60.32％升高至70.21％,对照侧由55.63％升高至68.47％,但两侧升高程度无明显差异(P＞0.10).治疗后患者的SAS评分为20.86±6.44,较治疗前(21.62±5.99)下降(P＜0.05);SDS评分为23.33±5.12,较治疗前(25.05±4.21)亦显著降低(P=0.024).结论 复合中层酸联合30％超分子水杨酸治疗黄褐斑,能显著改善患者的面部皮损情况及心理状态;先使用复合中层酸,再使用30％超分子水杨酸可取得更好效果.
Abstract
Objective To evaluate the therapeutic efficacy of a combination of compound mid-dle-layer acid and 30％supramolecular salicylic acid for melasma.Methods Five female pa-tients with melasma who were admitted to our hospital from May 2022 to December 2022 were en-rolled in this study.A self-parallel controlled study was carried out.The patients'treated side was treated with compound middle-layer acid while the control side was treated with 30％supramolecu-lar salicylic acid at weeks 0 and 4.On week 8,the treated side and control side were treated with 30％supramolecular salicylic acid and compound middle-layer acid,respectively.We compared the area score of facial lesions,skin color,sebum,water content and the severity of melasma-re-lated psychological stress between the two sides.Results The combination therapy significantly decreased the area scores on the forehead,cheek and chin(P＜0.05).In contrast,only the area scores on the forehead were decreased on the control side.Although the color scores were de-creased on the forehead,cheek and chin of both sides,significant decrease was observed on the treated side(P＜0.05 vs.the control side).Similarly,both treatments increased sebum con-tent,with a prominent increase on the treated side(P＜0.05 vs.the control side).The changes in water content did not differ significantly between these two treatments(P＞0.10).Moreover,the combination therapy decreased both SAS(from 21.62±5.99 to 20.86±6.44,P＜0.05)and SDS scores(from 25.05±4.21 to 23.33±5.12,P＜0.05).Conclusions The combina-tion therapy of compound middle-layer acid and 30％supramolecular salicylic acid can significant-ly improve the facial skin lesions and psychological state of patients with melasma.Better results can be achieved by using compound middle-layer acid first,followed by 30％supramolecular sali-cylic acid.
关键词
黄褐斑/中层复合酸/水杨酸Key words
melasma/compound middle-layer acid/salicylic acid引用本文复制引用
基金项目
国家自然科学基金(81673085)
国家自然科学基金(81201241)
出版年
2023
国家科技期刊平台
NSTL
维普
万方数据