IL-17与痤疮相关性的研究进展
Advances in the study of the association between IL-17 and acne
段忆雪 1温炬 1秦思 1黄文彬 1李慕锦1
作者信息
- 1. 暨南大学附属广东省第二人民医院,广东 广州 510317
- 折叠
摘要
痤疮是一种累及毛囊皮脂腺单位的慢性炎症性疾病,发病机制较为复杂.目前认为其发病与雄激素水平、皮脂分泌过量、毛囊角化过度、痤疮丙酸杆菌(C.acnes)定植等因素有关.多种炎症因子在痤疮的发病机制中起作用,其中IL-17在痤疮患者的表皮、血清中高表达,且与痤疮的严重程度呈正相关,或成为痤疮的生物标志物,有助于痤疮的早期诊断.大量证据证明IL-17可能参与痤疮的发病过程,甚至可能占据主导地位,IL-17参与了痤疮的炎症级联反应,从而改变痤疮的炎症程度,但具体机制尚不明确.本文对IL-17与痤疮相关性的研究进展进行综述,探究拮抗IL-17在痤疮中起到的抗炎及治疗痤疮的作用,以期进一步探索IL-17在痤疮发病机制中的作用,并为痤疮的治疗提供新思路.
Abstract
Acne is a chronic inflammatory disease involving the sebaceous unit of hair follicles,with a complex pathogenesis.Currently,it is believed that the pathogenesis of acne is related to androgen levels,excessive sebum secretion,hyperkeratosis of hair follicles,C.acnes and others.In recent years,studies have revealed the pathogenic role of a variety of inflammatory factors in ac-ne,among which IL-17 is highly expressed in the epidermis and serum of acne patients,and its levels are positively correlated with the severity of acne,becoming a biomarker for early diagnosis of acne.A large amount of evidence indicates the involvement of IL-17 in the pathogenesis of ac-ne,possibly playing a dominant role.IL-17 is involved in the inflammatory cascade of various ac-ne,thereby changing severity of inflammation.But the specific mechanisms are not clear.This ar-ticle reviews the research progress of the correlation between IL-17 and acne,and discusses the anti-inflammatory and therapeutic effects of anti-IL-7 on acne,in order to determine the pathogen-ic role of IL-17 in acne.
关键词
痤疮/IL-17/IL-17A/痤疮丙酸杆菌Key words
acne/IL-17/IL-17A/C.acnes引用本文复制引用
出版年
2023
国家科技期刊平台
NSTL
维普
万方数据