摘要
报告1例足趾小汗腺汗孔癌.患者女,67岁,左足第三趾浸润性斑块3年.皮肤科检查:左足第三趾甲床浸润性斑块,呈棕红色,质硬,趾甲损毁,边缘增生隆起,表面结痂,界限不清.皮损组织病理检查示:肿瘤与表皮相连,与正常表皮界限清楚,向真皮内侵袭性生长;瘤体内见较多坏死,肿瘤细胞呈多形性、泡状,核大、深染,见多核和瘤巨细胞,可见较多病理性核分裂及不同程度的导管分化.免疫组化染色示:CK7、EMA、CK5/6阳性,p16弥漫阳性,p40、p63强阳性,Ki-67约60％～90％(+)o诊断为小汗腺汗孔癌.予Mohs显微外科手术扩大切除.术后愈合良好,现随访中.
Abstract
A case of eccrine porocarcinoma on the toe is reported.A 67-year-old female pres-ented with a 3-year history of infiltrated plaque on the left middle toe.Physical examination showed a hard infiltrated plaque covered with crusts in reddish brown color,with broken nail,ele-vated borders and blurry boundaries,on the nail bed of the left middle toe.Histopathological find-ings included a demarcated tumor connected to the epidermis with growth towards the dermis,tumor necrosis,large pleomorphic cells with vacuoles and large hyperchromatic nuclei,multinu-cleated giant cells,pathological mitosis and various degree of ductal differentiation.Immunohisto-chemistry showed positive for CK7,EMA,CK5/6,p16,p40 and p63,and 60％～90％of Ki-67 positive.The diagnosis was eccrine porocarcinoma.Lesion was removed by Mohs microsurgery,and the follow-up is ongoing.
国家科技期刊平台
NSTL
维普
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