细菌性阴道病的治疗进展
Progress in the treatment of bacterial vaginosis
叶德晓 1游泽芳 1柴将红1
作者信息
- 1. 广东华润顺峰药业有限公司,广东 佛山 528300
- 折叠
摘要
细菌性阴道病(BV)是育龄期女性最常见的一种复杂的多菌性阴道感染性疾病,与阴道微生态失衡相关,患病率及复发率高,严重影响患者生活质量.指南推荐的治疗方案为口服或阴道内使用甲硝唑、克林霉素和替硝唑,近几年国外有指南新增了口服塞克硝唑和地喹氯铵阴道片.指南方案短期可有效缓解症状,但治疗后仍有较高的复发率.因此,近年研究较多涉及提高治愈率和降低复发率的替代方案方面,如其他抗菌剂、益生菌、益生元、酸化剂、中药和阴道微生物群移植等.本文对BV的治疗进展进行综述,以期为临床应用提供参考.
Abstract
Bacterial vaginosis(B V)is the most common complex and multi-bacterial infections of vagina in women of childbearing age,with a higher prevalence and recurrence rate.The patho-genesis of BV is linked to microbiota imbalance in the vagina.BV can severely impact the quality of patients'lives.The treatment guidelines recommend to use oral or intravaginal metronidazole,clindamycin and tinidazole.In recent years,oral secnidazole and vaginal tablets of dequalinium chloride are included in the guidelines abroad.Although these treatments can achieve short term benefit,the recurrence rate is still high.Therefore,research has been focused on the development of alternative therapeutic options,including other antibacterial agents,probiotics,prebiotics,a-cidifiers,traditional Chinese medicine and transplantation of vaginal microbiome,which can im-prove the cure rate while decreasing recurrence rate.This review summarizes the progress in the treatment of bacterial vaginosis in order to benefit clinicians in clinical practice.
关键词
细菌性阴道病/阴道菌群/指南方案/替代方案Key words
bacterial vaginosis/vaginal microbiome/guidelines/alternative approaches引用本文复制引用
出版年
2023
国家科技期刊平台
NSTL
维普
万方数据